2015 Fiscal Year Final Research Report
Role of meiotic specific cohesin in germ cell tumor and lung cancer.
| Project/Area Number |
26870150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
Respiratory organ internal medicine
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Goto Yasushi 国立研究開発法人国立がん研究センター, 中央病院, 医員 (20596374)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | タンパク / 抗体 / 減数分裂特異的コヒーシン / DNA修復 / DNA障害 |
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| Outline of Final Research Achievements |
We analysed for the meiosis specific, cancer testis antigen SMC1beta in cancer tissues. Role of SMC1beta in cancer cells is unknown, and there is a report that it has no effect on chromosome segregation after the DNA damage. We tried to assess the expression level of SMC1beta by immune-staining. However, through fully experiment, we could not find the condition to progress for the analysis for the SMC1beta in human specimen.
Since many proteins are related to DNA repair, analysis of specific protein is not enough to predict the human response. We are looking to analyse the related protein more comprehensively,
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| Free Research Field |
抗がん剤治療
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