Identification of stroke susceptible genes in the stroke-spontaneously hypertensive rats and evaluation of its molecular pathogenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870376
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine; Experimental pathology
• Research Institution: Shimane University
• Principal Investigator: Hiroki Ohara 島根大学, 医学部, 助教 (10609225)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脳卒中易発症高血圧自然発症ラット / コンジェニックラット / 脳卒中感受性遺伝子

Outline of Final Research Achievements

In the previous study, we showed that two genomic regions on rat chromosome (chr) 1 and 18 determines most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we performed a microarray-based screening to identify promising candidate genes by using SHRSP, stroke-resistant SHR and two of reciprocal congenic strains (Pr1_18 and Rp1_18) covering the quantitative trait loci (QTL) on chr 1 and 18. Quantitative expression analysis for miRNA on the chr 1 QTL was also performed.

Free Research Field

実験病理学