A method for generating molecular-targeting tools: Protein kinase-oriented library based on conformationally constrained peptide

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry; Chemical biology
• Research Institution: Osaka Prefecture University
• Principal Investigator: Fujiwara Daisuke 大阪府立大学, 理学(系)研究科(研究院), 助教 (30611420)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: プロテインキナーゼ / 阻害剤 / ペプチド / ライブラリー / ファージディスプレイ / オーロラキナーゼ / 細胞膜透過性

Outline of Final Research Achievements

Protein kinase takes roles of signal transduction or cell division of living cells. The biological functions of over 500 members of protein kinases are still not fully understood because of the lack of specific molecular tools to examine each protein kinase. Aberrant protein kinases cause diseases, and their specific inhibitors based on such molecular tools are expected to be therapeutics. Here we developed a new method to design and generate specific protein kinase inhibitors. This method would contribute to generate novel molecular tools in biology and also give therapeutic leads.

Free Research Field

ケミカルバイオロジー、ペプチド科学、進化分子工学