2015 Fiscal Year Final Research Report
Functional analysis of RNases as novel anti-cancer drugs
| Project/Area Number |
26870527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
Biological pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
TATSUTA Takeo 東北薬科大学, 薬学部, 助教 (70438563)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | リボヌクレアーゼ / レクチン / 抗腫瘍作用 |
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| Outline of Final Research Achievements |
A sialic acid-binding lectin derived from Bullfrog eggs (SBL) has both lectin and ribonuclease activity. It has been revealed that SBL demonstrates anti-tumor effect. In this time, we constructed recombinant proteins of SBL and other antitumor ribonucleases and performed cross-link experiments to identify their receptor-like molecules . Furthermore, we assessed anti-tumor effect of SBL against several malignant mesothelioma cell lines.
As a result, the actin has identified as the receptor-like molecule candidate . Furthermore, SBL exhibited more wide-ranging and cancer cell selective anti-tumor effect compared to existing drug such as pemetrexed. And also, combination treatment of SBL and pemetrexed showed synergistic anti-tumor effect. These results indicate that SBL could be a novel kind of anti-cancer drug.
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| Free Research Field |
生物系薬学
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