2016 Fiscal Year Final Research Report
Involvement of Organic anion Transporting Polypeptide 4C1 in mechanism of methotrexate-induced lung injury
| Project/Area Number |
26870584
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
Applied pharmacology
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺胞上皮細胞 / OATP4C1 / EMT / 肺線維化 / メトトレキサート |
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| Outline of Final Research Achievements |
Our present study revealed that, at least in part, intracellular accumulation of MTX in alveolar epithelial cells via organic anion transporting polypeptide 4C1 (OATP4C1) resulted in the induction of pulmonary fibrosis in OATP4C1 knockdown mice. Additionally, we found that changing from alveolar cells to myofibroblast through EMT also resulted in the induction of pulmonary fibrosis. Thus, our results suggest that both EMT and OATP4C1 are important determinants for causing MTX-induced pulmonary fibrosis.
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| Free Research Field |
薬剤性肺線維症
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