Regulations of Hepatic and pancreatic autonomic nerves by leptin and application to improvement of glucose metabolism

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870672
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology); Metabolomics
• Research Institution: Kanazawa Medical University
• Principal Investigator: TANIDA Mamoru 金沢医科大学, 医学部, 講師 (70512309)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 自律神経 / レプチン / 糖代謝 / 肝臓 / 視床下部 / 細胞内シグナル伝達 / 糖尿病

Outline of Final Research Achievements

Diabetes mellitus is one of serious health problem. In this experiment, we used animals and examined effects of leptin, appetite suppressor, on autonomic nerves to the liver and the pancreas which play an important role in regulating glucose metabolism, and cleared possible role of leptin in diabetes therapy. We showed that leptin stimulated liver autonomic nerves through the hypothalamic molecular signals. Thus, our evidence suggest that leptin may be useful reagent for diabetes treatment via the brain.

Free Research Field

生理学