Molecular hydrogen control the disease state of nonalcoholic steatohepatitis and prevent cancer by modifying gene expression by influencing the epigenetic mechanism of histone methylation modification

2017 Fiscal Year Final Research Report

• Project/Area Number: 26870682
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Eating habits
• Research Institution: Chubu University
• Principal Investigator: SOBUE Sayaka 中部大学, 臨床検査技術教育・実習センター, 講師 (50513347)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 水素

Outline of Final Research Achievements

Nonalcoholic steatohepatitis (NASH) is one of lifestyle-related diseases drawing more attention in recent years and develops in patients with diabetes and/or dyslipidemia based on obesity. Molecular hydrogen has been shown to exhibit anti-inflammatory effect as well as an antioxidative effect. Therefore, we investigated whether the progression of liver cancer in NASH model mice can be suppressed by molecular hydrogen. We found that molecular hydrogen controls second hit of inflammation and oxidative stress leading to the onset of NASH, as well as protecting the mitochondria by modifying gene expression by influencing the epigenetic mechanism of histone methylation modification, simultaneously inducing mtUPR.

Free Research Field

分子生物学