2017 Fiscal Year Final Research Report
Genetic/epigenetic interaction in the gastric carcinogenesis
| Project/Area Number |
26870685
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
Gastroenterology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 胃癌 / 遺伝子変異 / 遺伝子メチル化 / 分子サブタイプ |
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| Outline of Final Research Achievements |
To clarify the role of genetic/epigenetic interaction in the gastric carcinogenesis, we investigated genetic/epigenetic anomalies of primary gastric cancer, adjacent gastric mucosa and non-neoplastic gastric mucosa from cancer-free, but H. pylori positive patients, who are at risk for developing gastric cancer. We showed that molecular subtypes, combining genetic/epigenetic anomalies is associated with prognosis of gastric cancer patients. We also showed that DNA methylation status in the non-neoplastic gastric mucosa is associated with its morphologic features.
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| Free Research Field |
消化管内科
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