2015 Fiscal Year Final Research Report
Investigation of the role of intracellular CO using a supramolecular heme protein model complex showing high CO affinity
| Project/Area Number |
26870704
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical biology
Bio-related chemistry
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 内因性一酸化炭素 / ポルフィリン / シクロデキストリン / ヘムタンパク質 / 超分子化学 |
|---|
| Outline of Final Research Achievements |
Carbon monoxide (CO), a well known toxic gas, is continuously produced in the living body. Although the endogenous CO is considered to function in the biological system, the role of CO in biology has not been fully understood. Here, to investigate the biological function of endogenous CO, we utilized a supramolecular heme protein model complex, hemoCD, to remove endogenous CO from the living organisms. HemoCD was capable of quantitatively removing endogenous CO in the mice body due to its extremely high CO affinity. As a result, we succeeded to completely remove CO from the mice body, in which we found a biological feedback mechanism of endogenous CO to compensate the lack of Co in the living organisms (J. Am. Chem. Soc. 2016, 138, 5417-5425).
|
| Free Research Field |
生体内超分子化学
|
