2015 Fiscal Year Final Research Report
Elucidation of phospholipid metabolism necessary for life
| Project/Area Number |
26870879
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
General medical chemistry
|
|---|
| Research Institution | National Center for Global Health and Medicine |
|---|
Principal Investigator |
Yoshida Tomomi 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (30610216)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 発生医学 / 生体膜リン脂質 |
|---|
| Outline of Final Research Achievements |
This study demonstrated that LPCAT3, which is one of lysophospholipid acyltransferase, played a key role in biosynthesis of arachidonic acid containing phospholipids in vivo. LPCAT3-deficient mice showed a lethal phenotype within one week after birth. We also found that a triacylglycerol (TG) accumulation occurred by LPCAT3 deletion in small intestine at postnatal day 1. The study showed that an arachidonic acid containing phospholipid was important for an efficient TG transfer by an enzymatic assay in vitro. A glucose level and a TG level in blood were decreased in LPCAT3-deficient mice because enterocyte was disrupted by the accumulation. These results suggested that the dysfunction of enterocyte was one of the reasons for the neonatal lethal phenotype.
|
| Free Research Field |
脂質生化学
|
