2015 Fiscal Year Final Research Report
On the role of the anterior cingulate cortex in goal-directed instrumental behaviour in rats
Project/Area Number |
26885079
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Experimental psychology
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Research Institution | Keio University |
Principal Investigator |
Kosaki Yutaka 慶應義塾大学, 先導研究センター, 研究員 (80738469)
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Keywords | 道具的学習 / 目的的行動 / S-R習慣 / 連合過程 / 前帯状皮質 / 損傷 |
Outline of Final Research Achievements |
Instrumental behaviour of animals, including humans, is theorised to be mediated by two distinct processes. One is a process where a stimulus-response (S-R) association reinforced by the outcome of the response. The other is a goal-directed process, in which animals are sensitive to the contingency between response and its outcome as well as to the expected value of the outcome. In the current study, I examined the contribution of the peri-genual anterior cingulate cortex (ACC) to these distinct processes underlying instrumental behaviour. Using the contingency-degradation procedure and the outcome devaluation procedure, I found that the rats with ibotenic acid-induced lesions of the ACC performed comparably to the sham-lesioned control animals, in either of these tests. The results suggest that the peri-genual ACC, in contrast to the more anterior prelimbic cortex, is not crucial for the goal-directed control of instrumental behaviour.
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Free Research Field |
行動神経科学
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