The role of NF-kB in Ras-modulated remodeling of the actin cytoskeleton

2015 Fiscal Year Final Research Report

• Project/Area Number: 26890024
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: Konan University
• Principal Investigator: KAWAUCHI KEIKO 甲南大学, 甲南大学フロンティアサイエンス学部, 講師 (40434138)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: がん / NF-kB / p53 / アクチン / ミトコンドリア

Outline of Final Research Achievements

Actin cytoskeleton plays an important role in invasion, and metastasis of cancer cells. Accumulated evidence revealed that the tumor suppressor p53 prevents aggressiveness of cancer cells via remodeling of the actin cytoskeleton although the molecular mechanism has not been well studied. Since p53 is known to suppress NF-kB activity, we thought that NF-kB is involved in remodeling of the actin cytoskeleton modulated by dysfunction of p53. In this study, we showed that NF-kB prevented RAS-induced cleavage of b-actin through maintain mitochondria integrity, which might lead to invasion of cancer cells.

Free Research Field

分子生物学