Elucidation of the acquisiton mechanism of therapeutic resistance using imaging of genetic response to tumor hypoxia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893005
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: TAKEUCHI YASUTO 北海道大学, 遺伝子病制御研究所, 博士研究員 (10735187)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 低酸素 / 悪性腫瘍 / レポーター遺伝子 / 治療抵抗性 / SPECT / PET / 核医学 / 分子イメージング

Outline of Final Research Achievements

The aim of this study is to compare the tumor uptake level and tracer distribution of hypoxia-targeted PET tracers with those of gene activation levels by hypoxia-responsive elements (HRE). The tumor uptake level of hypoxia-targeted PET tracers reflected the gene activation level by HRE, which eventually conferred the resistance to anti-cancer therapies on the tumor cells and tracer distribution of 18F-FMISO PET might be more suitable than that of 64Cu-ATSM PET for planning hypoxia-targeted radiotherapy.

Free Research Field

医歯薬学