Development of a novel therapy for chronic pain patients by enhancing the descending pain inhibiroty systems via BDNF signalings

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893032
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology
• Research Institution: Gunma University
• Principal Investigator: Suto Takashi 群馬大学, 医学(系)研究科(研究院), 助教 (60739621)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 慢性痛 / 神経障害性疼痛

Outline of Final Research Achievements

Chronic nerve injured animals showed decreased prefrontal cortex function including cognition. They also showed decreased pain evoked pain inhibition. Treatment with TrkB receptor agonist (7,8-dihydroxyflavone) partially restored those impairment of PFC related function as reported before. TrkB agonist also restored pain evoked analgesia via noradrenergic activation. Immnohistochemistry of Locous coeruleus suggested the TrkB agonist improves excitation of noradrenergic neurons in locous coeruleus. Microdialysis studies are scheduled to examine the balance of glutamate and GABA signalings in locous coeruleus.

Free Research Field

麻酔科学