Analysis on the possibility of various tissue regeneration with the Nanogel possesing a molecular chaperone function

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893073
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Miyahara Takayuki 東京医科歯科大学, 歯学部附属病院, 医員 (30735246)
• Research Collaborator: KASUGAI Shohei 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70161049) ; SHIOTA Makoto 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (90196353) ; TACHIKAWA Noriko 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70236537) ; KURODA Shinji 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50323689) ; NAKATA Hidemi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30451967) ; AKIYOSHI Kazunari 京都大学, 工学研究科高分子化学専攻, 教授 (90201285) ; SHIMODA Asako 京都大学, 工学研究科高分子化学専攻 (90712042) ; HASHIMOTO Yoshihide 東京医科歯科大学, 生体材料工学研究所生体機能修復研究部門, 物質医工学分野助教 (40638384)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 骨再生 / GBR / Nanogel / membrane / collagen

Outline of Final Research Achievements

The purposes of this study were to analyze the gene expression, radiography and histology of nanogel for (1) bone regeneration, (2) soft tissue regeneration, and (3) nerve tissue regeneration. (1) The radiological analysis as bone regeneration revealed that the amount of newly formed bone in both nanogel groups were higher than collagen group (there were significant differences). (2) Histological evaluation of the soft tissue regeneration revealed that the healing of soft tissue in nanogel membrane group was better than that in silicon membrane and collagen one. (3) Evaluation of nerve tissue regeneration will be conducted in our future study. Clinical application will be demanded.

Free Research Field

インプラント 骨再生