2015 Fiscal Year Final Research Report
Identification drosophila VNUT
| Project/Area Number |
26893154
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
Kato Yuri 岡山大学, 学内共同利用施設等, 助教 (10732042)
|
|---|
| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | ATP / 小胞型ヌクレオチドトランスポーター / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
ATP acts as a major chemical transmitter in purinergic chemical transmission, which is involved in a variety of neurological phenotypes such as sensory and pain perception. Vesicular nucleotide transporter (VNUT/SLC17A9) is responsible for vesicular storage and release of ATP in neuroendocrine cells. In this study, we identified drosophila VNUT and found a specific inhibitor of VNUT. VNUT-/- drosophila showed significant phenotypes.
|
| Free Research Field |
トランスポーター生化学
|
