2015 Fiscal Year Final Research Report
The effect of epileptic discharges on cognitive function: a near-infrared spectroscopy analyses
| Project/Area Number |
26893189
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Keywords | てんかん / 発達障害 / 脳波 / 近赤外線スペクトロスコピー |
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| Outline of Final Research Achievements |
The main purpose of this study was to elucidate how epileptic discharges physiologically affect cognitive function in developmental disorders such as autism spectrum disorder. We conducted simultaneous measurement of electrical activity with electroencephalography and blood concentration change with near-infrared spectroscopy. We found that epileptic discharges induced the increase of oxy-hemoglobin and reduction of deoxy-hemoglobin. This suggests that epileptic discharges influence the oxygen and energy metabolism in the cerebral cortex. We also found that the cerebral blood change patterns depended on the locations of the discharges. This study will serve as the basis for future research to further clarify the association of the epileptic discharges with cognitive function in developmental disorders.
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| Free Research Field |
小児神経学
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