Elucidation of glial cell neurotrophic factor GDNF by the control mechanism for the inflammation that occurs in the pulp and bone

2015 Fiscal Year Final Research Report

• Project/Area Number: 26893244
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: SAITO NORIKO 九州歯科大学, 歯学部, 助教 (40735099)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Keywords: 象牙芽細胞様細胞 / GDNF / 細胞生存 / 再生医学

Outline of Final Research Achievements

We report the effect of GDNF-secreting ECB device, which allows constitutive secretion of glial cell neurotrophic factor (GDNF). These devices were provided by NsGENE, which is our collaborative company. Our result of ELISA assay indicate that GDNF continued secreting it from those devices for 12 months, and it was revealed that we could maintain those devices. We found that maintenance medium that was derived from those devices raised cell viability of odontblast like cell (KN-3 cell) under 0.1% serum.
These data suggest that GDNF-secreting ECB device are available to maintain odontblast viability and proliferation.

Free Research Field

歯内療法学