2015 Fiscal Year Final Research Report
The construction of 3 dimensional intestinal tract and mucosa model and the basic examination using oligonucleotide medicine.
Project/Area Number |
26893307
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
|
Research Institution | Osaka Ohtani University |
Principal Investigator |
WATANABE Chie 大阪大谷大学, 薬学部, 助教 (30737747)
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Keywords | 核酸製剤 / 腸管粘膜再構築モデル |
Outline of Final Research Achievements |
In this study, the basic model of 3 dimensional intestinal tract and mucosa was reconstituted in vitro using several biological materials. The model was also examined by the oligonucleotide medicine or materials which had different molecular sizes. This basic model was important for the substitutional assay system of animal experimental models which predict drug absorption and pharmacokinetics and for the precise analysis where in vivo analysis could not achieve.
|
Free Research Field |
薬剤学
|