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1988 Fiscal Year Final Research Report Summary

Ultrastructural study on the pathogenesis of interstitial pulmoary diseases

Research Project

Project/Area Number 60440034
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionJichi Medical School

Principal Investigator

YOKOYAMA Takeshi  Jichi Medical School Professor, 医学部, 教授 (30048938)

Co-Investigator(Kenkyū-buntansha) HIROTA Norio  Jichi Medical School Associate Professor, 医学部, 助教授 (20041361)
MOCHIZUKI Makoto  Jichi Medical School Assistant, 医学部, 助手 (60200333)
SHINOHARA Naohiro  Jichi Medical School Assistant, 医学部, 助手 (50192109)
SHIMIZU Hideo  Jichi Medical School Lecturer, 医学部, 講師 (80129030)
Project Period (FY) 1985 – 1988
KeywordsInterstial pneumonia / Extension fixation of lung / Diffuse alveolar damage / Ultrastructural research / Three dimensional research / 薬剤による間質性肺炎
Research Abstract

We studied the changes of human interstitial pulmonary disease, i.e. idiopathic interstitial pneumonia, diffuse panbronchiolitis, bronchobronchiolitis obliterans etc. The examined lungs were fixed in the state of normal inflation by polyethylenglycol after Heizman's method (1984). The fixed lungs were cut to thin small pieces or thin large segments and examined stereomicroscopically, scanning electron micro-scopically and by micro- and micro-softex, and also histological serial sections were 3-dimensionally by Cosmozone (NIKON). In order to study the histogenesis of interstitial pneumonia we also examined experimental Paraquat and hyperoxygen lungs of rats. In addition we studied human oncostatics-induced pulmonary changes. Results and Conclusions: The lungs of idiopathic interstitial pneumonia showed diffuse thickening of alveolar septa and bronchioloectasis in the periphery of the lungs (honeycomb lung), and in some cases also collapse of alveoli with fibrosis. The scanning electron … More microscopical findings of diffuse panbronchiolitis showed starfish-shaped fibrosis in which stenosed and thickened respiratory bronchioles were seen. The neighbouring alveoli revealed overinflation. The remarkable findings of broncho-bronchiolitis obliterans examined by macrosoftex showed stenosis of non-respiratory bronchioles and spherical dilatation of the proximal portion of the stenosed ones. The lungs of rats which were administered with Paraquat or hyperoxygen (80%) showed so-called "diffuse alveolar damage DAD". The findings of DAD of rat lungs were reversible degeneration and desquamation of the endothelial cell of the pulmonary capillaries, degeneration and necrosis of type 1 pneumocytes with hyaline membrane, swelling and regeneration of type II pneumocytes, edema followed by fibrosis in the alveolar septa. Organization of the exudated hyaline membrance and fibrous thickening of the alveolar septa narrowed the alveolar ducts and alveolar spaces. The pathogenesis of human idiopathic interstitial pneumonia was regarded as DAD which was also induced experi-mentally with Paraquat or hyperoxygen in the rat lungs. The oncostatics-induced human pulmonary changes of malignant hematopoietic disease cases were interstitial pneumonia with diffuse or scattered focal intraalveolar organization (fibrosis). Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 二ノ村信正: 日本胸部疾患学会雑誌. 24. 437-445 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清水英男: 日本胸部疾患学会雑誌. 23. 873-881 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 横山武: 病態生理. 7. 405-407 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 横山武,宮城千鶴子,林幹人: J.Toxicol.Pathol.1. 129-136 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 角田尚久,横山武外: 第29回日本胸部疾患学会総会発表予定. (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山中晃,横山武: "肺病理アトラス" 文光堂, 264 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 横山武: "原因不明の肺疾患(特発性間質性肺炎など)現代病理学大系 第14巻" 中山書店,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.,Ninomura: "Histopathological analysis of pulmonary findings of 40 autopsy cases in paraquat poisoning" Journal of Japan Society of Chest Diseases. 24. 437-445 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.,Shimizu: "Pathological study of lung cancer associated with idiopathic interstitial pneumonia" Journal of Japan Society of Chest Diseases. 23. 873-881 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.,Yokoyama: "Electron microscopic study on the pathogenesis of interstitial pneumonia" Pathologic Physiology. 7. 405-407 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.,Miyagui: "Adverse effects of oncostatics upon the lungs in cases of malignant hematopoietic diseases" Archives of Jichi Medical School. 11. 43-51 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.,Yokoyama: "Pathology of drug-induced pulmonary changes" Journal of Toxicologic Pathology. 1. 129-136 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.,Yamanaka: Altas of pulmonary pathology. Bunkohdo/Tokyo, 264 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Yokoyama: Cryptogenic lung diseases. Asakura Book-Publisher, (in prepation)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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