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1987 Fiscal Year Final Research Report Summary

Clinical applications and Influence on Tumor Infiltrating Lymphocytes of Anti-pulmonary carcinoma Monoclonal antibodies.

Research Project

Project/Area Number 60480321
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTokyo Medical College

Principal Investigator

NIITSUMA Masayuki  Tokyo medical College, Lecturer, 医学部, 講師 (70150662)

Co-Investigator(Kenkyū-buntansha) KATO Harubumi  Tokyo Medical College, Associate Professor, 医学部, 助教授 (20074768)
KAWAMURA Ichita  Tokyo Medical College, Professor, 医学部, 教授 (70074599)
HAYATA Yoshihiro  Tokyo Medical College, Professor, 医学部, 教授 (30074470)
Project Period (FY) 1985 – 1987
KeywordsMonoclonal antibody / Tumor markers / Immunological eytology / Immunotherapy / 毒性
Research Abstract

Tumor markers for the diagnosis of lung cancer were investigated. Adenocarcinoma of the lung showed high levels of SLX, CEA, and CA19-9, squamous cell carcinoma of the lung showed high levels of CEA, CA19-9 and SCC and small cell carcinoma of the lung showed high levels of NSE. These results indicated that the combination of tumor markers, SLX, CEA, CA19-9, SCC and NSE should be useful for the detsermination of the histologic type of lung cancer. In small cell carcinoma, there are many varieties of surface antigens,differing between cases or between primary tumors and metastatic lymph node involvement in the same indivisual. These results suggested that immunological characterization of small cell carcinoma cells should be helpful to investigate the resistance against anti-cancer drugs by recurrent or metastatic small cell carcinoma of the lung. Peripheral bolld lymphocytes from the patients with lung cancer have natural killer (NK) activiyty and killer activity against cultured lung cancer cells and these activities can be enhanced by Interleukin-2. These results suggested that the use of combination immunotherapy of monoclonal antibodies and biological response modifiers for the treatment of lung cancer holds significant potential advantages. Experiments concerning the toxicity of monoclonal antibodies in many animal models showed no severe side effects. These results indicate that monoclonal antibodies will be useful for the diagnosis and the treatment of lung cancer.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 於保健吉, 新妻雅行 他: 呼吸. 5. 308-313 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 早田義博, 新妻雅行: 日本外科学会雑誌. 87. 477-481 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新妻雅行 他: 外科治療. 55. 35-40 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 於保健吉, 新妻雅行 他: 手術. 41. 581-587 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新妻雅行 他: 老人科診療. 8. 260-263 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 於保健吉, 新妻雅行 他: 日本外科学会雑誌. 88. 1071-1074 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新妻雅行 他: "外科診療QUESTIONS & ANSWERS, 肺癌免疫療法の方法" 六法出版社, (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 新妻雅行 他: "外科診療QUESTIONS & ANSWERS, 肺癌の外科療法後の成績" 六法出版社, (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenkichi Oho, Masayuki Niitsuma, et al.: "Treatment programs for adenocarcinoma of the lung." Respiration Research. 5. 308-313 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihiro Hayata and Masayuki Niitsuma: "Current lung surgery" Journal of Japan Surgical Society. 87. 477-481 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Niitsuma, et al.: "Diagnosis and treatment of early stage lung cancer." Surgical Therapy.55. 35-40 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Niitsuma, et al.: "Lung cancer." The Journal of Geriatric Practice. 8. 260-263 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenkichi Oho, Masayuki Niitsuma, et al.: "Diagnosis and treatment by biological characteristics of lung cancer." Journal of Japan Surgical Society. 88. 1071-1074 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Niitsuma, et al.: Roppo Publishing Company.Immunotherapy for lung cancer., (1986)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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