1986 Fiscal Year Final Research Report Summary
Graft rejection mechanism by monocytes and specific immunosuppression.
| Project/Area Number |
60480357
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Osaka University Medical School |
|---|
Principal Investigator |
SONODA Takao Osaka University Hospital, Department of Urology,Professor, 医学部, 教授 (80028290)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKANO Etsuji Osaka University Hospital, Department of Urology,Associate Prof., 医学部, 講師 (90116070)
ISHIBASHI Michio Osaka University Hospital, Department of Urology,Associate Prof., 医学部, 講師 (40107032)
|
|---|
| Project Period (FY) |
1985 – 1986
|
| Keywords | Renal Transplantation / Monocytes / Rejection / インフルエンザウイルス |
|---|
| Research Abstract |
We investigated whether a novel monocyte, or spontaneous plaque-forming cell (SPFC), is related with renal allograft rejection in man , and how SPFC generation may be regulated in vitro. A auto-rosette-forming T cell (ARFC-T) may act as helper cell of SPFC-monocyte, while non-ARFC-T and ARFC-monocyte may act as suppressor of SPFC generation. Other environmental antigens, such as influenza virus, cytomegalovirus and E.Coli lipopolyssacharide, and allo-PBMC of man can affect the SPFC generation. In vivo SPFC response can be reflected in the invading cells from rejected grafts, detected by the in vitro MLC-SPFC assay. A definite correlation between graft survival and in vitro SPFC response was observed, that is, an excellent renal allograft survival was shown in the non-response patients of SPFC. The present results suggest that a novel monocyte, SPFC, may relate to renal allograft rejection and that a further study of SPFC-monocyte will give a key to open a new immunosuppression.
|
Research Products
(2 results)
