1986 Fiscal Year Final Research Report Summary

Antiphagocytic factor of oral strains of Bacteroides intermedius

Research Project

Project/Area Number	60480398
Research Category	Grant-in-Aid for General Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	Morphological basic dentistry
Research Institution	Showa University
Principal Investigator	TAKAMORI KENSHIRO School of Dentistry, Showa University, 歯学部, 教授 (80013853)
Co-Investigator(Kenkyū-buntansha)	IGARASHI TAKESHI School of Dentistry, Showa University, 歯学部, 助手 (10159585) YAMAMOTO AYAKO School of Dentistry, Showa University, 歯学部, 助教授 (20085773)
Project Period (FY)	1985 – 1986
Keywords	Bacteroides intermedius / Fibrous capsule / Amorphous capsule / Antiphagocytic factor IgK / <C_3> / 多糖体
Research Abstract	Oral Bacteroides intermedius possess capsules of two type were examined for their capability of resistant to phagocytosis by PMN. Fibrous capsulated strains had been high resistant to phagocytosis. In contrast, its of amorphous were readily phagocytosed. Bacterial cells of fibrous capsulated strain grown in broth possessed large amont of visoosus polysaccharide ( PS ). This PS was found to consist of galactose and mannose in the rate of 1 : 7. and had capability of high resistant when determined by sensitivity to phagocytosis of PS coated particle or IgG or <C_3> conjugated beads in the presence of PS. The results indicated that the PS from fibrous capsule of Bacteroides intermedius is involved in resistant to phagocytosis and inhibit uptake induced by IgG or <C_3> .