1986 Fiscal Year Final Research Report Summary
The investigation of antiviral resistance factor of nude mice infected with a mouse adenovirus
Grant-in-Aid for General Scientific Research (C)
NUKINA Keiko Tokai University, School of Medicine, 医学部, 助手 (20056302)
HASHIMOTO Kazuo Tokai University, School of Medicine, 医学部, 教授 (00055659)
|Project Period (FY)
1985 – 1986
|nude mice / mouse adenovirus / cyclophosphamide / interferon / ナチュラルキラー活性
Oral challenge of nu/nu mice with mouse adenovirus strain K87 results in the proliferation of virus in the intestinal tract. Resistance to the virus appears at around 6 wks post-infection which is considerably delayed in comparison to that exhibited by the euthymic mouse.
This resistance in the nu/nu mouse is seen without accompanying rise of neutralizing-antibody titer and complement-dependent neutralizing antibody titer.
Also interferon titer and the level of natural killer activity do not rise upon virus infection. This resistance does not disappear when nu/nu mouse is treated with anti asialo GM 1 or carrageenan.
On the other hand, this resistance completely disappears when nu/nu mouse is injected with cyclophosphamide.
Furthermore, while IgG level in the serum of nu/nu mouse is high, the level decreases after the injection of cyclophosphamide.