1987 Fiscal Year Final Research Report Summary
The Effect of Nitrogen Oxides on Bronchial Reactivity and Sensitivity
| Project/Area Number |
60570247
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
JUN KAGAWA Tokyo Women's Medical College;Professor, 医学部, 教授 (90055955)
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| Co-Investigator(Kenkyū-buntansha) |
SATORU SHIMIZU Tokyo Women's Medical College; Instructor, 医学部, 助手 (70158963)
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| Project Period (FY) |
1985 – 1987
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| Keywords | Nitrogen dioxide / Nitrogrnoxides / Bronchial reactivity / Bronchial sensitivity / Histamine |
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| Research Abstract |
In order to investigate the effect of repeated exposure to 0.5 ppm NO_2 on bronchial response to histamine challenge, 24 male Hartley guinea pigs were exposed to 0.5 ppm NO_2 or filteres air for 5 hr/days, 5days/week, for 11 weeks. Evary 10 days, boy weight, total respiratory flow resistance and bronchial reacivity to histamine aerosol were determined. In NO_2 group, a tendency of dectrase of body weight was observed. The effective concentration of histamine that produced a 100% increase of baseline total respiratory flow resistance before histamine challenge (PC_<100>) in NO_2 group was lower than that of filters air group during the first several weeks of exposure. However. these differences between NO_2 and filtered air groups were small and not statistically significant.
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Research Products
(4 results)
