1987 Fiscal Year Final Research Report Summary
Physiology and Biochemistry of Fibronectin; Comprehensive Approaches from Basic to Clinical Studies.
| Project/Area Number |
61300006
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
広領域
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| Research Institution | Ochanomizu University |
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Principal Investigator |
MASAO Hayashi Department of Biology, Ochanomizu University, 理学部, 助教授 (60110516)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Teruo Kinki University School of Medicineversity, 医学部, 講師 (80036475)
NAGATA Kazuhiro Chest Disease Research Institute, Kyoto University, 結核胸部疾患研究所, 教授 (50127114)
SENO Nobuko Department of Chemistry, Ochanomizu University, 理学部, 教授 (40017182)
SUZUKI Sakaru Department of Chemistry, Nagoya University, 理学部, 教授 (50022504)
UMEZAWA Kazuo Institute for Microbial Chemistry, 副所長 (70114402)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Fibronectin / Cell attachment / Cell spreading / Glycoprotein / 血漿タンパク質 |
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| Research Abstract |
The aim of this research project is to investigate basic and clinical physiology and biochemistry of cell-adhesive glycoproteins, especially fibronection. Results are summarized as follows. 1. An effective mass of a cell attachment site in fibronectin was estimated as 90 KDa from analyzing inactivation by X-ray exposure. 2. Fibronectin is suggested to play an important role in tissue organization of human placenta, because placenta synthesized placenta-specific fibroncctin. 3. From studies on relationship between fibronectin and oncogenes, some antibiotics suppressing oncogene function increased both amounts of fibronectin mRNA and fibronectin synthesis. 4. Concentration of fibronectin in human blood is found to relate to the nutritive conditions. 5. In rheumatoid arthritis, fibronectin on the cartilage surface is found to play an important role in promoting pannus extension onto the articular surface. 6. In tissue organization, the combination of fibronectin and proteoglycans together with their cell surface receptors is found to regulate attachment and spreading of cells to substrate. 7. Corneal epithelial cells prepared freshly did not express fibronectin rceeptor. They changed to express the receptor during wound healing.
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