1989 Fiscal Year Final Research Report Summary
Development of subunit-vaccine derived from glycoprotein complex with in the envelope of human cytomegalovirus
| Project/Area Number |
61480216
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
YABUUCHI Hyakuji Professor, Department of Pediatrics, Osaka University, 医学部, 教授 (20028335)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKI Kimiyasu Department of Virology, Research Institute for Microbial Diseases, Osaka Univers, 微生物病研究所, 助手 (50135745)
YAMANISHI Koichi Department of Virology, Research Institute for Microbial Diseases, Osaka Univers, 微生物病研究所, 助教授 (10029811)
BABA Koichi Department of Pediatrics, Osaka University, 医学部, 講師 (10127235)
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| Project Period (FY) |
1986 – 1988
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| Keywords | cytomegalovirus / subunit-vaccine / humoral antibody / cellular immune response / 細胞性免疫 |
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| Research Abstract |
A group of envelope protins of human cytomegalovirus, gA protein, and protein mixtures, prepared from WI-38 cells infected with Town strain, induced neutralizing antibodies and a cellular immune response in quinea pigs.
The same preparations of envelope proteins of the virus were in sufficient for development of immune response in children without specific antibody.
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Research Products
(9 results)
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[Publications] 馬場宏一,三上泰司,山本よしこ,田中和子,井藤尚之,金崎巧,河敬世,藪内百治,川原央好,岡田正,佐治文隆,谷澤修,石橋道男,高原央郎,小角幸人,園田孝夫: "血液製剤、輸血、臓器移植とレトロウイルス感染症" 小児科. 28. 559-569 (1987)
Description
「研究成果報告書概要(和文)」より
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[Publications] 山西弘一,白木公康,奥野良信,高橋理明,石橋道男,小角幸人,高原央郎,園田孝夫,馬場宏一,田中和子,金崎巧,藪内百治: "ヒトサイトメガロウイルス・サブユニットワクチンの開発研究(1)-腎移植術後のサイトメガロウイルス感染症の実態調査-" 厚生省予防接種研究班報告書「予防接種副反応の軽減化と後遺症患者の社会復帰に関する研究」. 224-245 (1987)
Description
「研究成果報告書概要(和文)」より
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[Publications] Okuno T, Higashi K, Shiraki K, Yamanishi K, Takahashi M, Kokado Y, Ishibashi M, Takahara S, Sonoda T, Tanaka K, Baba K, Yabuuchi H, Kurata T.: "Human Herpesvirus 6(HHV-6) Infection in Renal Transplantation" Transplantation. (1989)
Description
「研究成果報告書概要(欧文)」より
