1987 Fiscal Year Final Research Report Summary
Evaluation of myocardial edema by nuclear magnetic resonance spectorometer
| Project/Area Number |
61480300
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kinki University School of Medicine |
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Principal Investigator |
SHIROTANI Hitoshi Kinki University school of Medicino , Professor, 医学部, 教授 (60113156)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Osamu Kinki University School of Medicine , Assistant Professor, 医学部, 病院講師 (90177402)
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| Project Period (FY) |
1986 – 1987
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| Keywords | nuclear magnetic resonance / reperfusion injury / myocardial edema / 保存心 |
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| Research Abstract |
The reperfusion injury is one of the very important problems for open heart surgerys and heart transplantations. The preservation of reperfusion injury will lead these operations to good results. Because of this we have done research on myocardial edema caused by reperfusion injury. We have used nuclear magnetic resonance spectorometer (NMR) to evaluate intramyocardial high energy phosphate in rabit hearts. At this time we attempted to use NMR to evaluate intramyocardial edema by making good use of shift reagents. Poly-L-aspartic acid and poly-L-glutamic acid were used to distinguish between intravascular space and intramyocardial space. The results of thw experiment with some shift reagents is as follows.
shift(ppm) broadning (Hz)
0.1MCe 1.0
Nd 2.2
Fe(II) 4.3 62
Fe(III) wide
Co 5.4 76
Ni 2.1 89
Cu 0.8 80
Mn wide
As a result, we decided to use 40mM Co which is combined with poly-L-glutamic acid.
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