1987 Fiscal Year Final Research Report Summary
Analysis of neuro oncogenesis by genetically different susceptible strains of rats.
| Project/Area Number |
61570175
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
ITO Akihiro Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所, 教授 (60034633)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Masashi Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助手 (20127674)
WATANABE Hiromitus Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助教授 (00034653)
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| Project Period (FY) |
1986 – 1987
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| Research Abstract |
This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.
By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.
Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.
The study has been extended to analyze the genetical background in more details.
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[Publications] Takahashi, T., Watanabe, H., Nakagawa, Y., Mori, M., Aoyama, H. and Ito, A.: "Tumorigenecity Study in B6C3F_1 mice by Califorinium-252_<1.2.3.>" J. Radiation Research.29. (1988)
Description
「研究成果報告書概要(欧文)」より
