1987 Fiscal Year Final Research Report Summary

Establishment of a new method for the diagnosis of differentintestinal diseases by determination of serum bile acids.

Research Project

Project/Area Number	61570325
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	University of Tsukuba
Principal Investigator	OSUGA Toshiaki University of Tsukuba, Instiyute of Clinical Medicine, 臨床医学系, 教授 (20010481)
Project Period (FY)	1986 – 1987
Keywords	Serum individual bile acid / oral loading of ursodeoxycholic acid Bacterial overgrowth syndrome / 腸内細菌過剰発育症候群 / 吸収不良症候群 / 鑑別診断
Research Abstract	We tried to establish a new method for the differential diagnosis of the bacterial overgrowth syndrome and the malabsorption syndrome by determining the serum bile acid. By the determination of the individual bile acids with use of high performance of liquid chromatography it was possible to diagnose the overgrowth syndrome,since free bile acid and deoxycholic acid were increased by deconjugation or 7a dehydroxylation by the intestinal bacteria, respectively. On the other hand , by the determination of plasma clearance curvve of total bile acids after oral loading of 500mg ursodexycholic acid it was possible to diagnose the malabsorption syndrome, since clearance curve became flat in the existence of malabsorption. Therefore, with use of both tests it was possible to make differential diagnosis between overgrowth syndrome and malabsorption syndromeby taking blood sample which has been impossible.

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