1987 Fiscal Year Final Research Report Summary

Trarable ischemic neuronal damage

Research Project

Project/Area Number	61570706
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Teikyo University Shool of Medicine
Principal Investigator	KIRINO Takaaki Teikyo Univesity School of Medicine, 医学部, 助教授 (10161605)
Co-Investigator(Kenkyū-buntansha)	TAMURA Akira Teikyo University Shool of Medicine, 医学部, 教授 (80111532)
Project Period (FY)	1986 – 1987
Keywords	Cerebral ishcimis / Selective vulnerabilty / Hippocampus / Prntobarbita / Benzodiazepine / Nizofenone / ベンゾジアゼピン / ニゾフェノン / 小脳虚血 / プルキエ細胞 / 局所脳虚血
Research Abstract	Brier transient forbrain ischemia in to Mongolian gearbil produces a selective neuronal damage in the hippocampus. Immeciately follwing ishemia, prentobarbvtal,diazapem, or nizotenone were given in gerbils. The neuronal density in the CA1 sector showed a significant inforease in the treated goups. when froug administration was delayed fro longer than 15 minutes, however, no definite eccets were found. The mechanism of selective vulnerability of ischemia is not fully understood. An experiment of cerbellar ischemia was done in order to compare thr pathological change with that og thr hippocampus. %cerebella purkinje cells showed ishiemic cell damage following 10 min of comression ischemia. The alteration was, however, much faster than taht in the hippocampus. The underlying mechanism seems to be different. Focal cetebral ischiemia is more frequently sdeen in clinical case. To tsudy the reversibility of neurons in focal ischema, rats were subjected to permanent unilatearal middle cerebral artery occtusion. In ischemic region, rapid prograssion in infaction was noticed and slow process as is seen in the hippocampus was not recognized. On the other hand, in the distant areas of the brain, such as the thalamus, and substntia nigra, a slow buyt proufnd morphological changes were obsearved. Transizent focal cerebral ischemia in the rat is now being studeid in order to examine the possibility of reversible neuronal change following brief focal ischemia.