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1988 Fiscal Year Final Research Report Summary

Quantitataive morphometrical study of the human nervous system change - Development of the research method using dimentional image processing system -

Research Project

Project/Area Number 61870021
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionUniversity of Tokyo

Principal Investigator

TOMONAGA Masanori  Faculty of Medicine, University of Tokyo, 医学部, 教授 (10072977)

Co-Investigator(Kenkyū-buntansha) 勝沼 英宇  東京医大, 老年科, 教授
萬年 徹  東京大学, 医学部, 教授 (10010208)
MURAYAMA Shigeo  Faculty of Medicine, University of Tokyo, 医学部, 助手 (50183653)
IKEDA Kazuhiko  Faculty of Medicine, University of Tokyo, 医学部, 助手 (30124663)
MANNEN Tohru  Faculty of Medicine, University of Tokyo
TOMONAGA Masanori  Faculty of Medicine, University of Tokyo (30078307)
KATUNUMA Eiu  Tokyo Medical College
Project Period (FY) 1986 – 1988
KeywordsImage analysis / Morphometry / Nerve cell / Peripheral nerve / 筋肉
Research Abstract

When we study the changes of human nervous system, especially in the field of neuropathology, we use qualitative method or quantitative method. For the latter, we have used mainly namual one, such as DIGIPLAN as the best. However, this method was very time-consumed when the number of the material was large. On the other hand, we have had also automatic morphometrical apparatus, such as QUANTIMET, however, which was not enough to differentiate the histological structure, because the capacity was restricted in discrimination of only the density. We tried to develope the quantitative system to differentiate and measure the structure by the color tone in the stained histological specimens. For this purpose we used dimentional image processor, nexus 6400, which was used in landsat technology. We developed the programs to measure the following structure : the number and size of nerve cells, arborization of dendrites, number of glia, the number, diameter and area of peripheral nerve and muscle.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 朝長正徳: 脳と神経. 40. 57-64 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 朝長正徳: 老人科診療. 9. 85-90 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 下手公一,朝長正徳 他: 日本老年医学会雑誌. 24. 513-518 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 福田準,吉村正博,河崎博,山之内博,葛原茂樹,嶋田裕之,朝長正徳: 日本老年医学会雑誌. 25. 480-485 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 朝長正徳: "アルツハイマー型老年痴呆" 藤田企画出版, (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 朝長正徳: "脳の老化とぼけ" 紀伊國屋書店, (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tomonaga, M.: "The size of nerve cells in the brain aging and Alzheimer's disease" Brain & Nerve. 40. 57-64 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomonaga, M.: "Brain aging - On the number of nerve cells in the brtains of normal and demented elderly persons." Geriatric Practice. 9. 85-90 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Simode, K.: "Patholgical study of the aging atrophy of the cerebellum of the aged." Japanese Journal of Geriatrics. 24. 513-518 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, J.: "Quasntitative study of the brain atrophy of the senile dementia of Alzheimer's type." Japanese Journal of Geriatrics. 25. 480-485 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomonaga, M.: Senile dementia of the Alzheimer's type. Fujita Kikaku Publishing, (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-12-19  

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