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1988 Fiscal Year Final Research Report Summary

Studies on non-A, non-B hepatitis.

Research Project

Project/Area Number 62304035
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNihon University

Principal Investigator

SHIKATA Toshio  Nihon University, Professor, 医学部, 教授 (50009932)

Co-Investigator(Kenkyū-buntansha) ICHIDA Fumihiro  Niigata University, Professor, 医学部, 教授 (90018292)
UCHIDA Toshikazu  Nihon University, Associate professor, 医学部, 助教授 (80060078)
ABE Kenji  National Institute of Health, Researcher, 研究員 (60130415)
MORITSUGU Yasuo  National Institute of Health, Head of hepatitis research unit., 室長 (40100101)
ONO Yasushi  Nihon University, Professor, 医学部, 教授 (30004675)
Project Period (FY) 1987 – 1988
KeywordsPost-transfusion non-A / non-B hepatitis / Epidemic non-A / non-B hepatitis
Research Abstract

Although a considerable number of works had been done to identify the causative virus of two types of non-A, non-B hepatitis, that is post-transfusion type and enterically-transmitted type, there was no reliable report about identification of cusative virus particles. Our research group sucessfully demonstrated virus particles of both non-A, non-B hepatitis for those 2 years. First, we inoculated fecal materials taken from patients with sporadic non-A, non-B hepatitis in Rangoon, Burma to the cynomolgus monkeys and we recovered virus particles from the bile of the infected animales. This virus was also successfully transmitted to the second and third generation of the animals. Concerning post-transfusion non-A, non-B hepatitis, we demonstrated virus particles in the sera of the infected chimpanzees after gradient centrifugation. Virus is 36 to 64nm in diameter and molphologicaly it resembles to togavirus. We are now trying molecular cloning of both viruses.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 志方俊夫: 総合臨床. 36. 1499-1504 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Abe: The Journal of Infecticus Disease. 155. 1078 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阿部賢治: 肝臓. 29. 705-706 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阿部賢治: 肝臓. 29. 1661 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 志方俊夫: 代謝. 25. 29-33 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 志方俊夫: 診断と治療. 76. 1851-1856 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshio Shikata.: "Recent advances in non-A, non-B hepatitis research." Sogo Rinsho. 36. 1499-1504 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Abe.: "Prognosis and progression of non-A, non-B hepatitis; Long-term follow up study in chimpanzees." Acta Hepatologica japonica. 29. 705-706 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Abe.: "Detection of virus-like particles in no non-A, non-B hepatitis infected chinpanzee's sera." Acta Hepatologica japonica. 29. 1661 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshio Shikata.: "Process and prosperity of the study for non-A, non-B hepatitis." Nihon Rinsho. 46. 2564-2574 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yohko K. Shimuzu.: The hpatitis delta virus and its infection.Alan R.Liss,Inc.Ltd., 51-60 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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