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1989 Fiscal Year Final Research Report Summary

Experimental and Clinical Study to the Mechanism of Exercise-induced ST Elevation in Chronic Myocardial Infarction

Research Project

Project/Area Number 62480212
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionYamagata University School of Medicine

Principal Investigator

YASUI Shoji  Yamagata Univ. Sch. of Med. Professor, 医学部, 教授 (20023781)

Co-Investigator(Kenkyū-buntansha) IKEDA Kozue  Yamagata Univ. Sch. of Med. Assistant, 医学部, 助手 (30184419)
TONO-OKA Ichiro  Yamagata Univ. Sch. of Med. Assistant, 医学部, 助手 (70164001)
太田 郁郎  山形大学, 医学部, 助手 (70143097)
KUBOTA Isao  Yamagata Univ. Sch. of Med. Instructor, 医学部, 助教授 (30161673)
TSUIKI Kai  Yamagata Univ. Sch. of Med. Associate Professor, 医学部, 助教授 (30004683)
YAMAKI Michiyasu  Yamagata Univ. Sch. of Med. Assistant (40191217)
Project Period (FY) 1987 – 1989
KeywordsChronic myocardial infarction / Right atrial pacing / Exercise test / ST elevation / Epicardial ECG mapping / Body surface ECG mapping / Ventricular depolarization
Research Abstract

The purpose of this study is to investigate the mechanism of exercise- induced ST elevation in patients previous myocardial infarction. We approached this problem by canine experiment of 1-month old infarction and by exercise test in patients with previous myocardial infarction.
Experimental Study: We constructed experimental myocardial infarction in 6 mongrel dogs by ligation of the left anterior descending artery. One month after, epicardial mapping of 60 leads was performed during the right atrial pacing. The frequency of pacing increased from 120 bpm, by 20 bpm for each 3 min, until 240 bpm. The electrocardioraphic data was simultaneously recorded by CD-0055 and transmitted to a personal computer, PC9801. For each lead, timeintegrals from the onset of QRS to the offset of QRS, from the offset of QRS to the offset of T, and from the onset of QRS to the offset of T (AQRS, ASTT, AQRST, respectively) were calculated. Infarcted area was determined by staining with nitroblue tetrazolium.
I … More n the infarcted area, AQRS was significantly decreased and ASTT was significantly increased by the increase of heart rate. Also, the amplitude of Q wave increased significantly. AQRST showed no significant changes. On the other hand,in the non-infarcted area, none of AQRS, ASTT or AQRST changed significantly.
Clinical Study: We performed body surface electrocardiographic mapping in 68 patients with previous myocardial infarction, before and after the symptom limited treadmill exercise. The ECG mapping data was recorded by HPM5100 or VCM3000. For each lead, AQRS, ASTT, and AQRST were calculated. In the Infarcted area, AQRS decreased significantly, and ASTT and AQRST increased significantly by exercise. Also, the amplitude of Q wave increased significantly.
These results demonstrated that the decrease of AQRS was associated with the increase of ASTT both in the right atrial pacing and exercise test in chronic myocardial infarction. We conclude that changes in the ventricular depolarization (QRS) by the increased heart rate contributed to the exerciseinduced elevation of ST segment in the chronic myocardial infarction. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 細谷幸雄・本間健太郎・中村和治・池田こずえ・安井昭二: "一ヶ月梗塞犬の心房ペ-シング負荷時の心表面ST-T変化の検討" 心電図. 9. 601 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Konta,K.Ikeda,M.Yamaki,K.Nakamura,K.Honma,Y.Hosoya,I.Kubota,S.Yasui: "Significance of discordant ST alternans for the induction of ventricular fibrillation" Eur Heart J. 10. 165 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 細谷幸雄・池田こずえ・八巻通安・久保田功・立木楷・安井昭二他: "陳旧性下壁梗塞患者の運動負荷前後のST isointegralmapの検討" 心電図. 8. 514 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村和治・池田こずえ・八巻通安・今田剛・本間健太郎・小沢竹俊・安井昭二: "急性心筋虚血時の心表面VAT等時線図の変化" 心電図. 8. 516 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 細谷幸雄・池田こずえ・八巻通安・久保田功・立木楷・安井昭二他: "心筋梗塞患者の運動負荷前後の体表面電位図変化ST-T isointegral mapによる検討" 心電図. 7. 411 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seiji yasumura Isao Kubota,Kozue Ikeda,Michiyasu Yamaki,Kai Tsuiki,Shoji Yasui: "ST segment changes in exercise body surface mapping after myocardial infarction in patients with isloated left anterior descending coronary artery disease." Am Heart J. 114. 1120-28 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuhiro Endo,Kozue Ikeda,Michiyasu Yamaki,Isao Kubota,Kai Tsuiki,Shoji Yacui.: "The correlation of the treadmill exercise test with cardiac hemodynamics in patients with previous myocardial infarction." Jpn Heart J. 53. 283-290 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukio Hosoya, Kentaro Honma, Kazuharu Nakamura, Kozue Ikeda, Shoji Yasui: "Epicardial ECG mapping of 1-month-old myocardial infarction during atrial pacing." Jpn J Electrocardiol Vol 9, pp601, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Konta, K.Ikeda, M.Yamaki, K.Nakamura, Y.Hosoya, I. Kubota, S.Yasui: "Significance of discordant ST alternans for the prediction of ventricular fibrillation." Eur Heart J Vol 10, suppl. pp165, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukio Hosoya, Kozue Ikeda, Michiyasu Yamaki, Isao Kubota, Kai Tsuiki, Shoji Yasui, et al.: "Changes on the ST isointegral maps by exercise in patients with chronic inferior myocardial infarction." Jpn J Electrocardiol Vol 8, pp514, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuharu Nakamura, Kozue Ikeda, Michiyasu Yamaki, Tsuyoshi Konta, Kentaro Honma, Taketoshi Ozawa, Shoji Yasui: "Changes in the epicardial VAT map following acute coronary artery ligation." Jpn J Electrocardiol Vol 8, pp516, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukio Hosoya, Kozue Ikeda, Michiyasu Yamaki, Isao Kubota, Kai Tsuiki, Shoji Yasui, et al.: "Exercise-induced electrocardiographic changes in patients with previous myocardial infarction. Analysis by the STT isointegral maps." Jpn J Electrocardiol Vol 7, pp411, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seiji Yasumura, Isao Kubota, Kozue Ikeda, Michiyasu Yamaki, Kai Tsuiki, Shoji Yasui: "ST segment changes in exercise body surface mapping after myocardial infarction in patients with isloated left anterior descending coronary artery disease." Am Heart J Vol 114, pp1120-28, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiro Endo, Kozue Ikeda, Michiyasu Yamaki, Isao Kobota, Kai Tsuiki, Shoji Yasui: "The correlation of the treadmill exercise test with cardiac hemodynamics in patients with previous myocardial infarction." Jpn Heart J Vol 53, pp283-290, 1989.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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