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1988 Fiscal Year Final Research Report Summary

Experimental radiology for prevention and control of metastasis

Research Project

Project/Area Number 62480237
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tokyo

Principal Investigator

SUZUKI Norio  University of Tokyo, Faculty of Medicine, Professor, 医学部, 教授 (10010050)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shozo  University of Tokyo, Institute of Medical Science, Research Associate, 医科学研究所, 助手 (30012743)
TANGE Tuyoshi  University of Tokyo, Faculty of Medicine, Lecturer, 医学部, 講師 (10107667)
HARII Kiyonori  University of Tokyo, Faculty of Medicine, Professor, 医学部, 教授 (50111539)
MAJIMA Hideyuki  University of Tokyo, Faculty of Medicine, Research Associate, 医学部, 助手 (60165701)
SAKAI Kazuo  University of Tokyo, Faculty of Medicine, Research Associate, 医学部, 助手 (40153837)
Project Period (FY) 1987 – 1988
KeywordsPrevention and control of metastasis / CTCR assay / X-rays / neutrons / murine tumors / dose fractionation / OK432
Research Abstract

The present study aimed to obtain basic infomaiton, which could be useful in clinical situation. The processes of hematogenous metastasis can be divided into three steps,i.e., tumor cell release from the primary into the blood circulation, transportation, arrest and growth at the secondary site. All of these steps are important and have to be considered in the study for prevention and treatment of metastases.
In the first year, we studied effect of neutron irradiation of local tumors on clonogenic tumor cell release and metastasis formation. The results indicated neutron suppressed clonogenic tumor cell release and metastasis more effectively than X-rays. In the current year, the effect of intratumoral injection of OK432 on metastasis formation was investigated using various tumor systems including immunogenic or nonimmunogenic. Only intratumoral injection was effective in nonimmunogenic tumor systems although either i.p or i.m./s.c. in the opposite leg to the inoculated tumor was aslo effective in immunogenic tumor systems.
The suppression of lung metastasis formation by intratumoral injection of OK-432 was paralleled with the reduction of clonogenic tumor cell release into the blood circulation.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Suzuki,N.: Radiat.Res.1. 269 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,N.: Radiat.Med.5. 801-803 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,N.: In Rodent Tumor Models in Experimental Cancer Therapy. 95-96 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, N.: "Tumor blood perfusion and clonogenic tumor cell release in metastasis." Radiation Research. 1. 269 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N.: "Effect of low doses of whole body irradiation on spontaneous lung metastasis of NFSA2ALMI mouse tumors." Radiation Medicine. 5. 801-803 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N.: "A new metastasis system derived from a mouse fibrosarcoma(NFSa) of spontaneous origin and its "clonogenic" tumor-cell-release rate."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N.: "Metastatic potential of transplantable SqIISlml carcinoma of WHT/Ht mouse."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N.: "Suppression of metastasis from mouse leg tumors by local irradiation and injection of OK432."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N.: Clonogenic tumor cell release assay and its applicaiton to tumor biology In "Rodent Tumor Models in Experimental Cancer Therapy". Pergamon Press, New York., 95-96 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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