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1989 Fiscal Year Final Research Report Summary

Experimental investigation of heart-lung transplantation

Research Project

Project/Area Number 62480292
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionUniversity of Tokyo

Principal Investigator

FURUSE Akira  Dept.of Thoracic Surgery, Faculty of Medicine, University of Tokyo, Professor, 医学部(病), 教授 (70010163)

Co-Investigator(Kenkyū-buntansha) YOKOI Yasushi  Dept. of Thoracic Surgery, Faculty of Medicine, University of Tokyo, Associate, 医学部, 助手 (60192415)
MATHISON Megumi  Dept. of Thoracic Surgery, Faculty of Medicine, University of Tokyo, Associate, 医学部(病), 助手 (20164212)
NAKAJIMA Jun  Dept. of Thoracic Surgery, Faculty of Medicine, University of Tokyo, Associate, 医学部(病), 助手 (90188954)
KAWAUCHI Motohiro  Dept. of Thoracic Surgery, Faculty of Medicine, University of Tokyo, Associate, 医学部(病), 助手 (00152918)
Project Period (FY) 1987 – 1989
KeywordsHeart-lung transplantation / Japanese monkey (Macaca Fuscata) / Allotransplantation and Autotransplantation / Chest roentogenogram / Asynchronous rejection of the heart and the lung / Tracheal findings / Myosin light chain level / 気管所見 / ミオシン軽鎖
Research Abstract

Experimental evaluations were done in Japanese monkeys (macaca fuscata) about orthotopic heart-lung allotransplantation, orthotopic heart-lung autotransplantation, and heterotopic heart allotransplantation.
In orthotopic heart-lung allotransplantation,eight recipient monkeys survived for three to thirty three days. Their respiratory pattern changed considerably after the transplantation.
The chest roentogenogram in the early postoperative period showed the central cloudiness and enhancement of the interstitial change, alid these findings reached their peak between the fifth and eighth postoperative day. Pathological study revealed no obvious round cell infiltration in the lung of this stage.
Asynchronous rejections of the heart and the lungs following the allotransplantation were observed in two monkeys. Moderate cardiac rejection and severe pulmonary edema without apparent round cell infiltration were observed in one monkey, and vascular type mild pulmonary rejection without cardiac reje … More ction was recognized in the etlier monkey.
Histologic assessment of the donor trachea revealed that there was no significant change in the mucosal epithelium except for the squamous metaplasia which was observed in two monkeys. However,submucosal infiltration of round cell was observed in every monkey. The tracheas of allograft with moderate to severe rejection showed higher degrees of submoucosal cell infiltration than those with minimal to mild rejection.
In the orthotopic heart-lung autotrazisplantation, seven monkeys survived two to five days. Postoperative chest roentogenogram showed peribronchial and perivascular cuffing in the early postoperative period. Peribronchial and perivascular edema without or with minimal round cell infiltration was observed microscopically.
Measurement of the plasma myosin light chain level was done in the monkeys which were subjected to heterotopic cardiac allotransplantation,and it revealed to be of value in the monitoring of cardiac allograft rejection. Less

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 川内基裕、古瀬彰、進藤剛殻、松永仁、マティソン恵、横井泰、中島淳、吉竹毅ほか: "日本猿による同種同所心肺移植の検討。" 日本胸部外科学会雑誌. 36. 207-213 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川内基裕、古瀬彰、マティソン恵、中島淳、横井泰、岡輝明、吉竹毅: "日本猿による心肺同時移植におけるasynchronous rejection" 移植. 24. 73-79 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川内基裕、古瀬彰、マティソン恵、横井泰、中島淳、吉竹毅、岡輝明: "実験的心肺同時移植後の胸部X線写真上の変化と病理組織学的所見との比較検討" 日本胸部外科学会雑誌. 37. 65-72 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川内基裕、竹田誠、矢崎義雄、岡部英男、中島淳、守月理、古瀬彰: "移植心の拒絶反応の診断におけるミオシン軽鎖の意義。" 日本外科学会雑誌. 90. 795 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 川内基裕、古瀬彰、マティソン恵、横井泰、中島淳、守月理、岡輝明、吉竹毅: "ニホンザルによる同種心肺移植における拒絶反応の病理組織学的検討。" 移植. 24. 502-509 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawauchi M,Yazaki Y,Oka T,Okabe H,Mathison M,Nakajima J,Furuse A,et al.:"Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains." Japanese Journal of Surgery. 20. 212-216 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Motohiro KAWAUCHI, Akira FURUSE, Goki SHINDO, Hitoshi MATSUNAGA, Megumi MATHISON, Yasushi YOKOI, Jun NAKAJIMA, and Tsuyoshi YOSHITAKE: "Orthotopic heart and lung transplantation in Japanese monkey." J Jap Assoc Thorac Surg 36(2):207-213, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Motohiro KAWAUCHI, Akira FURUSE, Megumi MATHISON, Jun NAKAJIMA, Yasushi YOKOI, Teruaki OKA, and Tsuyoshi YOSHITAKE: "Asynchronous rejection of heart and lungs following cardiopulmonary transplantation in Japanese monkey." Jap J Transplant 24(1):73-79, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Motohiro KAWAUCHI, Akira FURUSE, Megumi MATHISON, Yasushi YOKOI, Jun NAKAJIMA, Tsuyoshi YOSHITAKE, and Teruaki OKA: "Roentogenologic pathologic evaluation of allograft rejection in heart-lung transplantation - an experimental study in Japanese monkey -" J Jap Assoc Thorac Surg 37(3):65-72, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Motohiro KAWAUCHI, Akira FURUSE, Megumi MATHISON, Yasushi YOKOI, Jun NAKAJIMA, Osamu MORIZUKI, Teruaki OKA, and Tsuyoshi YOSHITAKE: "Histological changes of the donor trachea following cardiopulmonary transplantation in Japanese monkey." Jap J Transplant 24(5):502-509, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Motohiro KAWAUCHI, Yoshio YAZAKI, Teruaki OKA, Hideo OKABE, Megumi MATHISON, Jun NAKAJIMA, Osamu MORIZUKI, Go KAWAGUCHI, Kenji KOSENI, Makoto TAKEDA, Masahide CHIKADA and Akira FURUSE: "Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains." Japanese Journal of Surgery 20(2):212-216, 1990.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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