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1988 Fiscal Year Final Research Report Summary

Cholestryl-ester transfer protein on development of atherosclerosis

Research Project

Project/Area Number 62570282
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionKANAZAWA UNIVERSITY

Principal Investigator

JUNJI KOIZUMI  Instructor, Second department of internal medicine, university hospital., 医学部付属病院, 助手 (20161846)

Co-Investigator(Kenkyū-buntansha) HIROSHI MABUCHI  Associate professor, Second department of internal medicine,school of medicine., 医学部, 助教授 (00019960)
Project Period (FY) 1987 – 1988
KeywordsCholestryl-ester transfer protein (activity) / Coronary heart disease / HDL-cholesterol / apoAI ratio / Familial hyperalphalipoproteinemia / Familial hypercholestrolemia / 冠動脈硬化
Research Abstract

Cholesteryl-ester transfer protein (CETP) transfers and exchanges cholesteryl esters between liporoteins. An increase of cholesteryl-ester transfer activities (CETA) may result in low levels of high-density-lipoprotein cholesterol (HDL-C). To investigate a role of CETP on progression or regression of atherosclerosis, CETA and HDL-C/apoAI ratio were examined in patients with familial hypercholesterolemia (FH) or coronary heart disease. Restriction fragment length polymorphisms (RFLP) of CETP gene were analyzed on FH or familial hyperalphalipoproteinemia with deficiency of CETA.
Coronary atherosclerosis indeces which were estimated from the findings of selective coronary cine angiogram, showed a negative correlation with HDL-C levels and HDL-C/apoAI ratios. The decrease of HDL-C level was related to the increase of apoB-containing lipoprotiens. On plasma of FH, there were significantly high activities of cholesteryl ester transfer between HDL and other lipoproteins, and a negative correlation between CETA and HDL-C/apoAI ratio. Taq I RFLP of CETP gene was analyzed in patients with familial hyperalphalipoproteinemia or FH. A familial hyperalphalipoproteinemic patient with CETA deficiency showed a homozygosity in RFLP of CETP gene. The relationship between HDL-C/apoAI ration and RFLP patten of CETP gene was recognized in members of a FH family.
These results indicated that CETA increased in hyperlipoproteinemia. The increase of CETA might cause an increase of atherogenic remnant cholesterol and a decrease of HDL-C, resulting in progression of atherosclerosis.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 馬渕宏: 動脈硬化. 15. 63-69 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小泉順二: 動脈硬化. 16. 53-57 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] JUNJI,KOIZUMI: Atherosclerosis. 74. 1-8 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] HIROSHI MABUCHI: "Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinemia." The journal of Japan atherosclerosis society. 15. 63-69 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] JUNJI KOIZUMI: "The effects of LDL-apheresis and plasma exchange on cholesterol level and lipid composition of low and high density lipoproteins in homozygous patients with familial hypercholesterolemia." The journal of Japan atherosclerosis society. 16. 53-57 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] JUNJI KOIZUMI: "Removal of apolipoprotein E-enriched high density lipoprotein by LDL-apheresis in familial hypercholesterolaemia ; a possible activation of the reverse cholesterol transport system." Atherosclerosis. 74. 1-8 (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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