1988 Fiscal Year Final Research Report Summary
Study of Idiopathic Proximal Tubular Dysfunction in Childhood
| Project/Area Number |
62570416
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
OKADA Toshio Faculty of Medicine, Toyama Medical and Pharmaceutical University, 医学部, 教授 (70018365)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Susumu Hospital of Toyama Medical and Pharmaceutical University, 附属病院, 助手 (10159949)
SUZUKI Yoshifumi Faculty of Medicine, Toyama Medical and Pharmaceutical University, 医学部, 助教授 (90086546)
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| Project Period (FY) |
1987 – 1988
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| Keywords | 1, Urinary screening examination in school / 2, Low molecular weight proteinuria / 近位尿細管性機能異常症 |
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| Research Abstract |
Idiopathic tublar dysfunction in childhood is ogten discovered by a routine screening examination in school or others. Until now we have experienced 7 cases of this disease. All patients were male and 4 of these were each brothers in two pairs. Marked urinary excretion of low molecular proteins was a only synptom in this disease, otherwise no evident clinical synptoms were found. Histological examination in some cases revealed no particular changes at onset. In the follow-up study of these patients, hypophosphatemia, aminoaciduria and glycosuria developed in some cases, however there are no patients with progressive deteriorated renal function or poor physical development. Although abnormal tubular reabsorption of low nolecular weight protein is considered as a basic mechanism, it is necessary to defferentiate this disease from other tubular disorders and to evaluate detailed historogical findings and genetic background. It is also necessay to follow up natural history of long term, to study disease frequency and distribution in the world and to elucidate more detailed pathogenesis.
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