1989 Fiscal Year Final Research Report Summary
A basic research on the development of enhancing agent for magnetic resonance imaging (MRI).
| Project/Area Number |
62570646
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Institute of Clinical Medicine, Tsukuba University |
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Principal Investigator |
NOSE Tadao Institute of Clinical Medicine, Univ.Tsukuba., Professor, 臨床医学系, 教授 (10009699)
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| Co-Investigator(Kenkyū-buntansha) |
NOSE Harumi Institute of Clinical Medicine, Univ.Tsukuba., Assistant Professor., 臨床医学系, 講師 (80009571)
ENOMOTO Takao Institute of Clinical Medicine, Univ.Tsukuba., Assistant Professor., 臨床医学系, 講師 (10134230)
TOMONO Yuji Institute of Clinical Medicine, Univ.Tsukuba., Assistant Professor., 臨床医学系, 講師 (70110335)
NAKAGAWA Kunio Institute of Clinical Medicine, Univ.Tsukuba., Assistant Professor., 臨床医学系, 講師 (40092077)
HOMMA Kazuhiro Mechanical Engineering Laboratory, MITT., バイオメカニクス課, 研究員
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| Project Period (FY) |
1987 – 1989
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| Keywords | Magnetic Resonance Image / Enhancing agents / Gd-DTPA / Iodine enhancing agent / Cold isotope / ^<19>F / Deuterium (D_2O) |
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| Research Abstract |
1. A study of phamacokinetics of GD-DTPA in vivo. The authors investigated a pharmacokinetics of Gd-DTPA using Ga-^<14>C-DTPA in experimental animals and obtained following results. (1) The enhancement effect of the agent for tumor itself is the strongest immediately after injection. (2) Gd-DTPA was not present in normal brain tissue. These results were reconfirmed by another experiment using autoradiography. In ischemic model Gd-DTPA was detected in the ischemic area 3 hours after cessation of blood flow. This result was reaffirmed by another experiment using autoradiography.
2. Para-magnetic effect of iodine enhancing agent. Iodine used as a enhanced agent in conventional X-ray imaging has also a effect on proton relaxation magnetic resonance image. The relaxation times of both T1 and T2 were shortened. This effect was though to be dose dependent. For clinical use the optimal dose was deduced as 10ml/Kg.
3. Effect of cold isotope for MRI. Among the non-radioactive isotopes, ^<99>Tc, ^<203>TI, ^<133>Xe, ^<57>Ga, ^<19>F and ^<111>In are thought to be effective for MRI enhancement. The authors investigated the MR spectroscopy of ^<19>F-FDG (fluorodeoxyglucose) and tried to express it two dimensionally. The ^<18>F-FDG concentrated 10 times of that used for PET (positron emission scanner) was needed to obtain a spatial resolution of 1cm in diameter.
4. A basic research on developing new method of measurement of cerebral blood flow using Deuterium (D_2O). The deuterium has a negative enhancement effect by replacing water and this in can be used for the measurement of CBF. The balue of CBF is calculated by obtaining signal chronologically from the deuterium influx into brain it into the rats abdominal cavity. The result showed good correlation to the other result deduced by routine methods using radioisotope.
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