1988 Fiscal Year Final Research Report Summary
BIOMECHANICAL ANALYSIS OF EXPERIMENTAL CHEMONUCLEOLYSIS
| Project/Area Number |
62570694
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
HIRABAYASHI Kiyoshi KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助教授 (60051413)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Nobuyuki KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (70164473)
KOYANAGI Takahiro KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (90162073)
ICHIMURA Shouichi KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (00159849)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Biomechanics / Chemonucleolysis / Viscoelasticity / Chymopapain / Collagenase / 動的粘弾性 / 振動工学 |
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| Research Abstract |
To study the mechanical properties of enzyme-injected intervertebral discs, quasi-static compression tests and dynamic vibration tests were performed on canine intervertebral discs 2weeks after enzyme injection (short-period group) and within 6 months (long-period group) respectively, and the findings in each group were compared with those of normal discs as a control.
The results of the quasi-static tests were as follows:in the short-period group, normalized stiffness of the discs was reduced significantly and the normalized creep rate was increased. The intradiscal pressures produced by external loading in short-period discs were almost half those of the control.in the long-period group such values tended to recover partially.
The results of the dynamic tests were as follows:in the sort- period group,both elasticity and viscosity were reduced,while in the long-period group elasticity recovered but viscosity did not. These findings suggest that the shock-absorbing ability of enzyme-injected discs does not recover.
Then, hydroxyapatite were inserted into the discs after collagenase injection to examine the possibility of ossification of the discs. But ossification could not be proved.
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Research Products
(4 results)
