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1989 Fiscal Year Final Research Report Summary

An experimental study on the mechanism of glaucomatous optic nerve damage.

Research Project

Project/Area Number 62570795
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionGifu University

Principal Investigator

KITAZAWA Yoshiaki  Gifu Univ. Sch. of Med., Professor, 医学部, 教授 (20009484)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Keiko  Gifu Univ. Sch. of Med., Instructor, 医学部, 助手 (10199838)
SUGIYAMA Kazuhisa  Gifu Univ. Sch. of Med., Instructor, 医学部, 助手 (80179168)
KAWAI Kenji  Gifu Univ. Sch. of Med., Instructor, 医学部・附属病院, 助手 (00169666)
TOMITA Goji  Gifu Univ. Sch. of Med., Assistant Professor, 医学部・附属病院, 講師 (30172191)
FUNAHASHI Masakazu  Gifu Univ. Sch. of Med., Associate Professor, 医学部, 助教授 (30112709)
Project Period (FY) 1987 – 1989
KeywordsExperimental glaucoma / Glaucomatous optic nerve damage / Image analysis / Retinal nerve fiber layer / Argon laser / 低眼圧緑内障 / 濾過手術
Research Abstract

We made experimental glaucomatous eyes in 10 eyes of 10 monkeys (Macaca Fuscatus) by repeated argon laser applications to the chamber angle. Changes in the optic nerve head were observed in vivo by a computerized three dimensional image analysis system (Optic Nerve Head Analyzer, Rodenstock, FRG), and in vitro by light and electron microscopy.
The optic disc topography was measured using the computerized image analyzer before laser application and at 3 to 12 weeks following the first laser treatment. The optic disc excavation increased in its depth, volume and size along with the elevation of the intraocular pressure. The rate of increase statistically significantly correlated with the height and the duration of the intraocular pressure. Immediately after the last measurements of the optic disc, the animals were sacrificed and the eyes were enucleated. The value of the optic disc area measured in enucleated eyes was in good agreement with that of the computerized image analysis system. Light and electron microscopy revealed that the axonal damage in the vicinity of the central vessels started first at the level of the lamina cribrosa, and extended to the periphery of the optic nerve. We also obtained a new finding that the retinal nerve fiber layer degeneration may occur at the time when the optic nerve damage is still mild. These results suggested the importance of the blood circulation disturbance as a causative factor of glaucomatous optic nerve head damage as well as the elevation of intraocular pressure.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 北川克明: "緑内障診療と視神経乳頭画像解析について" 日本眼科紀要. 40. 2833-2848 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北川克明: "The effect of Ca^<2+>-antagonist on visual field in low-tension glaucoma." Graefe's Arch Clin Exp Ophthalmol. 227. 408-412 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 船橋正員: "サル実験緑内障眼視神経乳頭部の病理学的所見について" あたらしい眼科.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 富田剛司: "コンピュ-ター画像解析装置IMAGEnetによる視神経乳頭解析ーOptic Nerve Head Analyzer(ONHA)との比較" 日本眼科学会雑誌. 93. 741-746 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松原恵子: "緑内障減圧手術後の乳頭陥凹変化についてー視神経乳頭画像解析装置による定量的観察ー" 日本眼科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松原恵子: "緑内障における視野変化と視神経乳頭画像解析結果の関連について" 日本眼科学会雑誌. 92. 1414-1418 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitazawa, Yoshiaki: "Image analysis of the optic disc and the diagnosis and therapy of glaucoma." Folia Ophthalmol Jpn 40:2833-2848, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsubara, Keiko: "Correlation of visual changes and optic disc measurements with computerized videographic image analyzer in glaucoma." Acta Ophthalmol Jpn. 92:1414-1418, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitazawa, Yoshiaki: "The accuracy of optic disc measurements with optic nerve head analyzer in vivo and in vitro study." Invest. Ophthalmol. Vis. Sci.(Supple.) 30:430, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitazawa, Yoshiaki: "The effect of Ca^<2+>-antagonist on visual field in low-tension glaucoma." Graefe's Arch Clin. Exp.Ophthalmol. 227:408-412, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomita, Goji: "Computerized digital image analysis of optic nerve heads with a three-dimensional image analyzer, IMAGEnet and a comparison with the Optic Nerve Head Analyzer." Acta Soc. Ophthalmol. Jpn. 93:741-746, 1989.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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