1988 Fiscal Year Final Research Report Summary
Pharmacological studies on animal models of Alzheimer disease and Senile dementia, and development of therapeutic drugs
| Project/Area Number |
62570979
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
WATANABE Hiroshi Department of Pharmacology, Research Institute for Wakan-Yaku, 和漢薬研究所, 教授 (10012642)
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| Project Period (FY) |
1987 – 1988
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| Keywords | animal model / Alzheimer disease / Senile dementia / vincristine / ドーパミン / アセチルコリン |
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| Research Abstract |
1. Animal models of alzheimer disease and senile dementia, and behavioral changes
(1) In rats treated with vincristine into the nuilateral striatum, apomorphine produced transient rotational behavior 2 to 3 days agter the treatment.
(2) Microinjection of vincristine into the bilateral striata prevented the acquisition and retention of spatial memory of rats 3 to 5 days after the injection. Since these rats died due to the paralysis of four legs by two to four weeks after the injection, vincristine-induced lesion was considered to be progressive.
2. Changes of neurotransmitters in the striatum of the model animals
(1) Measurement of catecholamines: Striatal dopamine and its metabolites slightly decreased 7 to 8 days after the intrastriatal microinjection of vincristine.
(2) receptor binding assay: [^3H]-spiperone binding to striatal membranes decreased after vincristine treatment. Further investigation is required to clarify if an animal model of alzheimer disease is sensitive to drugs.
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