1989 Fiscal Year Final Research Report Summary
Genetic improvement of acallosamal mice, and its physiological property.
| Project/Area Number |
62580033
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Kagawa Medical School (1987, 1989)
Shimane Medical University (1988) |
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Principal Investigator |
MURAKAMI Tetuhide Kagawa Medical School, Department of Biology, Professor., 医学部, 教授 (20032873)
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| Project Period (FY) |
1987 – 1989
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| Keywords | Acallogsal mouse / Genetic improvement / Cortical EEG / Kindling model / photic evoked potential |
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| Research Abstract |
The congenital acallosal mouse has been maintained in brother-sister mating in our laboratory since 1980. About 10% of adult mouse showed either complete or partial deficiency of the corpusc allosum. After five generations of full-sib inbreeding, a spontaneous change occurred in one line, resulting in more than 35% of adults with deficient corpus callosum.
The behavioral consequences of absent corpus callosum mice, there were no differences in the open-field activity and avoidance training.
The electrophysiologically, the cortical EEG in the complete acallosal mice, the correlation coefficients were significantly lower in crossed contralateral, left vs right hemispheres, and homotopic posterior to reference. The visual evoked field potential in acallosal mice, the latency, peek latency and duration of there potentials from ipsilateral side significantly prolonged, the amplitude of the potentials almost diminished. The penicillin-induced seizure and hypocampal kindling in acallosal mice displayed asymmetrical generalized seizures. The days required for kindling seizure were significantly shorter than in normal group.
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Research Products
(16 results)
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[Publications] Fukunishi,I.,Murakami,T.H.,Negi,T.,Usuki,T.Y.,Kugoh,T.,Okada,Y.and Hosokawa,K.: "Elsevier science Publishers.B.V.Amsterdam" Hatase,O.and Wang,J.H.(eds)Bioinformatics. 1989. (4)
Description
「研究成果報告書概要(和文)」より
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[Publications] Fukunishi,l.,Murakami,T.H.,Negi,T.,Ijada,Y.and Hosokawa,K.: "Elsevier science publishers.B.V.Amsterdam" Hatase,O.and Wang,J.H.(eds)Bioinformatics. 1989. (4)
Description
「研究成果報告書概要(和文)」より
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[Publications] Fukunishi, I., Murakami, T.H., Negi, T., Usuki, T.Y., Kugoh, T., Okada, Y. and Hosokawa, K.: "The role of corpus callosum in bilateral interhemispheric synchrony I. Penicillin-induced seizures in congenitally acallosal mice." Hatase, O, and Wang, J, H, eds, Bioinformatics, Elsevier Science Publishers. B. V. Amsterdam. 347-350 (1989)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Fukunishi, I., Murakami, T.H., Negi, T., Hamada, T., Okada, Y., and Hosokawa, K.: "The role of carpus callosum in bilateral interhemispheric synchrony II. Hippocampal kindling in congenitally acallosal mice." Hatase, O, and Wang, J, H, eds, Bioinformatics, Elsevier Science Publishers. B. V. Amsterdam, 347-350, 1989.
Description
「研究成果報告書概要(欧文)」より
