A study on the development of new bone a angmentation material composed of biodegradable poly-lactic acid and hydroxylapatite

1989 Fiscal Year Final Research Report Summary

• Project/Area Number: 62870078
• Research Category: Grant-in-Aid for Developmental Scientific Research
• Allocation Type: Single-year Grants
• Research Field: 補綴理工系歯学
• Research Institution: HIROSHIMA UNIVERSITY
• Principal Investigator: TSURU Hiromichi Hiroshima Univ. Sch. of Dent. Professor, 歯学部, 教授 (90034157)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Masaki Hiroshima Univ. Sch.of Dent. Fellow, 歯学部, 助手 (80189505) ; AKAGAWA Yasumasa Hiroshima Univ. Dental Hospital, Lecturer, 歯学部附属病院, 講師 (00127599) ; IKADA Yoshihito Kyoto Uni., Medical Center, Professor, 医用高分子研究センター, 教授 (00025909)
• Project Period (FY): 1987 – 1989
• Keywords: Polylactic acidapatite composite / Bioabsorbable polymer / Augmentation / Demineralized bone / Bone induction

Research Abstract

In order to develop a new bone augmentation material, some composite materials were fabricated from bioabsorbable polytactic acid (PLA), hydroxylapatite (HA) and demineralized rat femur particles (DP) and bone tissue reaction to these materials were histologically evaluated.
These composite materials were implanted subperiosteally over the parietal bone and the man dible with the framework of milipore-filter in 12 week-old Wistar rats. Histological examination revealed that the implantation of PLA-HA composite resulted in no bone formation, whereas DP composite induced marked new bone formation on the surface of the host bone.
These,results suggest that DP composite has a promising candidate as a new augmentation material and a new system using DP composite with milipore-filter framework may be a predictable method for bone augmentation.