1989 Fiscal Year Final Research Report Summary
Study on the reconstruction of the mandibular bone using Apatite porous block
| Project/Area Number |
62870082
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
外科・放射線系歯学
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| Research Institution | Yamanashi Medical College |
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Principal Investigator |
OHNISHI Masatoshi Yamanashi Medical College Professor, 医学部, 教授 (50014139)
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKI Kayoko Yamanashi Medical College Lecturer, 医学部, 講師 (20185325)
ICHIZYOU Takashi Tokyo Medical and Dental University Professor, 歯学部, 教授 (20013807)
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| Project Period (FY) |
1987 – 1989
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| Keywords | Apatite porous block / Bioactive material / Osteo-Conduction / Mandibular reconstruction / Segmental resection / Bone scintigraphy / Bio-dynamics / Titanium reconstruction plate |
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| Research Abstract |
Using animal experiments, the authors have been studying the morphological development of multiporous apatite blocks, and examining the bioaffinity of these blocks in vivo and the state of bone formation.
Based on the results of these animal experiments, clinical application of these blocks began in October 1980.
The aim of adapting apatite material as a substitute for the jaw bone can be roughly classified into two parts:(1) as a substitute shape, and (2) as a structural support. The former employs the method of planning the recovery and reformation of the bone shape when the extent of loss is small and the shape of the jaw bone needs to be transformed.
With this reconstruction method, after segmental resection, the lower jaw bone is left at both ends of the lost part, and in between them a bridge is made with the apatite. The bridge must therefore be fixed securely. Unfortunately, the apatite porous body is fragile, and the nature of the material does not allow it to be wired directly t
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o the mandibular bone. As a result, a frame structure support for the lower jaw bone is created by means of a metal plate reinforcement. For this purpose, we developed a metal plate made of titanium with a structure like that shown in. By screwing down the plate, the apatite block is firmly fixed in place, supported by the pressure welding of the bones from the front and rear, and the plate from outside and underneath.
The apatite bone substitute material as artificial living tissue is much easier to handle compared to the transplant of, for example, intestinal bone tissue or costa from living bone tissue for the reconstruction of the lower jaw bone. However, to obtain clinical results which equal reconstruction by living bone tissue using artificial living tissue material, a strict operation system and control are necessary where by maximum utility is achieved by fully considering the biodynamics of the material. For this purpose, it will be necessary to consider an operation that uses artificial bone in the same way as or more deeply than a bone transplant operation using living bone tissue. Less
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