• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1990 Fiscal Year Final Research Report Summary

Biomechanics of Cells, Tissues, and Organs of Living Organisms

Research Project

Project/Area Number 63300009
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionHokkaido University (1990)
Osaka University (1988-1989)

Principal Investigator

HAYASHI Kozaburo  Hokkaido Univ., Res. Inst. of Appl. Elect., Professor, 応用電気研究所, 教授 (90026196)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Teruo  Kyushu Univ., Fac. Eng., Dept. Mech. Eng., Professor, 工学部, 教授 (90091347)
TSUJIOKA Katsuhiko  Kawasaki Med. Univ., Associate Professor, 助教授 (30163801)
TANAKA Masao  Osaka Univ., Sch. Eng. Sci., Dept. Mech. Eng., Associate Professor, 基礎工学部, 助教授 (40163571)
SATO Masaaki  Tsukuba Univ., Fac. Basic Med., Dept. Biomed. Eng., Associate Professor, 基礎医学系, 助教授 (30111371)
AKAMATSU Tomoaki  Kyoto Univ., Fac. Eng., Dept. Mech. Eng., Professor, 工学部, 教授 (40025896)
Project Period (FY) 1988 – 1990
KeywordsBiomechanics / Cardiovascular mechanics / Respiratory mechanics / Artificial organs / Tissue mechanics / Cellular mechanics / Functional adaptation / Optimal design
Research Abstract

Structure and function of living cells, tissues, and organs have been studied from the standpoint of biomechanics, and the results have been applied to the development of the methods for the maintenance and strengthening of their function as well as for the recovery from malfunction.
The results obtained are :
1. Through the studies on the respiratory and circulatory mechanics, artificial organs mechanics, hard and soft tissue mechanics, and bio-dynamics, continuum mechanics was modified for the analyses of nonuniform, anisotropic, and nonlinear living systems, mechanical approach was developed for the biocompatibitity study of artificial organs, advanced novel techniques were reviewed for the observation and measurement of bio-phenomena, and basic methods were established for the study of gas-liquid-substance complexes found in living organisms.
2. Mechanical analyses of living cells have been started, and the current trends in cellular mechanics were reviewed and its future significance was evaluated.
3. For the scientific communication, most of the investigators for this project attended the ASME/JSME Tissue Engineering Symposium held in San Francisco in 1989, 1st World Congress on Biomechanics held in La Jolla in 1990, and 2nd JSME Conference on Biomechanics held at Osaka University in 1991.
4. Based on this project, a new project entitled "Biomechanics of structure and function of living cells, tissues and organs" has been proposed to the Ministry of Education, Science and Culture as a Grant-in-Aid for Scientific Research on Priority Area which starts in 1992.

  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] M.Sato: "Mechanical properties of cultured endothelial cells exposed to shear stress" Frontlers Med.Biol.Eng.2. 171-175 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "高圧多機能型人工肺システムの開発" 医科器械学. 60. 29-33 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "高圧気相型ホロ-ファイバ人工肺システムのinuitro実験による検討" 人工臓器. 19. 476-479 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 辻 隆之: "完全内挿型人工血管の実験的研究" 人工臓器. 19. 1331-1334 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 赤松映明: "ロ-ラポンプチュ-ブ内の流れと最適ポンプヘッド形状" 人工臓器. 17. 1400-1403 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Akamatsu: "Perfomance of a compact nutating centrifugal blood pump(Teaspoon pump)" Artificial Organs. 14. 30-33 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hayashi: "Biomechanical approach to the desigh of vascular prostheses" Tissue Engineeringー1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nakamura: "Effects of longーterm pumping of cardiac assist device on the left ventricular mechanics(In the case of normal heart)" Artifical Organs.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.yamamoto: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" ASME,Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Abe: "Mathematical model of the canine left ventricle during isovolumic and isobaric contractions" Progress and New Directions of Biomechanics. 123-130 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Sato: "Effect of wall shear rate on thrombogenesis in microーvessels of the rat mesentery" Circulation Research. 66. 941-949 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Sato: "Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties" ASME,Journal of Biomechanical Engineering. 112. 263-268 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Shino: "Arthroscopic followーup of anterior cruciafe ligament reconstrucion using allogenic tendon" J.Arthroscopic and Related Surgery. 5. 165-171 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ebara: "Motion analysis of the cervical spine in athetoid cerebral palsyーExtensionーflexion motin" Spine. 15. 1097-1103 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Shino: "Reconstruction田of the anterior cruciate ligament using allogeneic tendonーLongーterm followup" Am.J.Sports Medicine. 18. 457-465 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Kajiya: "Mechanical control of coronary artery inflow and vein flow" Jap.Circulation Journal. 53. 431-439 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Kajiya: "Analysis of the characteristics of the flow velocity waveforms in left atrial small arteries and veins in the dog" Circulation Research. 65. 1172-1181 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Goto: "Effect of blood filling in interamyocardial vessels on coronary arterial inflow" Am.Journal of Physiology. 258. H1042-H1048 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanishita: "Fluid flow in a strongly curved pipe" Frontiers Med.Biol.Eng.2. 187-191 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 谷下一夫: "徴孔性膜型人工肺の炭酸ガス除去性能" 日本機械学会論文集. 56. 3869-3873 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 谷下一夫: "きつい曲がり管における定常入口流れ" 日本機械学会論文集. 57. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tanaka: "A note on ACL deformarion under tensile loading along ligament and/or tibia direction" Tissue Engineeringー1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Seguchi: "Preliminary study on adaptation by remodeling" Tissue Engineeringー1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Wada: "Breathingーventilation model,and simulation of highーfreguency ventilation" JSME International Journal. 34. 98-105 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Murakami: "Effect of lubricants on improvement of fluid film formation in knee prostheses under walking condition" Progress and New Directions of Biomechics. 403-412 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Ohtsuki: "Frictional behavior of some knee prostheses in a knee joint simulator" Proc.Jap.International Tribology Conf.713-718 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Murakami: "The lubrication in natural synovial joints and joint prostheses" JSME International Journal. 33. 465-474 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matsuzaki: "Flow in a twoーdimensional collapsible channel with rigid inlet and outlet" ASME,Journal of Biomechanical Engineering. 111. 180-184 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matsuzaki: "Wave motions in a collapsible tube conveying fluid" Monographs on Atherosclerosis. 15. 138-149 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matsuzaki: "Analysis of flow in a twoーdimensional collapsible channel using universal “tube" law" ASME,Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Hayashi: "Biomechanical approach to the design of Vascular Prostheses" Tissue Engineeringー1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Abe and T. Nakamura: "Mathematical model of the canine left ventricle during isovolumic and isobaric contractions" Progress and New Directions of Biomechanics. 123-130 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Sato et al.: "Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties" ASME, J. Biomechanical Eng.Vol. 112. 263-268 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Tsuji et al.: "Development of intraluminal ceramic-ringed tapered graft with a newly invented introducing double balloon catheter" Jap. J. Artificial Organs. Vol. 19. 1331-1334 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Akamatsu: "Performance of a compact nutating centrifugal blood pump (Teaspoon pump)" Artificial Organs. Vol. 14, Suppl. 1. 30-33 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shino et al.: "Reconstruction of the anterior cruciate ligament using allogeneic tendon - Longーterm followup" Am. J. Sports Medicine. Vol. 18. 457-465 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Goto et al.: "Effect of blood filling in intramyocardial vessels on coronary arterial inflow" Am. J. Physiology. Vol. 258. 1042-1048 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Murakami and N. Ohtsuki: "The lubrication in natural synovial joints and joint prostheses" JSME International J.Vol. 33. 465-474 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Matsuzaki and T. Matsumoto: "Wave motion in a collapsible tube conveying fluid" Monographs on Atherosclerosis. Vol. 15. 138-149 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Tanishita et al.: "Fluid flow in a strongly curved pipe" Frontiers of Med. Biol. Eng.Vol. 2. 187-191 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Tanaka et al.: "A note on the ACL deformation under tensile loading along ligament and/or tibia direction" Tissue Engineering - 1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Seguchi et al.: "Preliminary study on adaptation by remodeling" Tissue Engineering - 1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-08-12  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi