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1990 Fiscal Year Final Research Report Summary

Eco-biotoxicology of Newly Developed Semiconductor Metals.

Research Project

Project/Area Number 63304038
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionUniversity of Tokyo

Principal Investigator

WADA Osamu  University of Tokyo, Department of Hygiene and Preventive Medicine, Professor, 医学部・医学科, 教授 (60009933)

Co-Investigator(Kenkyū-buntansha) YAMAMURA Yukio  St. Marianna University School of Medicine, Department of Public Health, Profess, 教授 (40081658)
MANABE Shigeo  University of Tokyo, Department of Hygiene and Preventive Medicine, Assistant pr, 医学部・医学科, 助教授 (90165928)
HORIGUCHI Shunichi  Osaka City University Medical School, Department of Preventive Medicine and Envi, 医学部, 教授 (60046828)
SHIMA Shogo  FuJita Health University School of Medicine, Department of Public Health, Profes, 医学部, 教授 (40084511)
ISHINISHI Noburu  Kyushu University, Department of Hygiene, Professor, 医学部, 教授 (80037340)
Project Period (FY) 1988 – 1990
KeywordsSemiconductor metals / Tumorigenicity / Immuno-toxicity / Mutagenicity / Embryonic toxicity / Arsenicals / Indium / Germanium
Research Abstract

Eco-bio-toxicological investigations on newly developed metal compounds as the semiconductor materials or biomaterials were carried out to obtain basic toxicological data.
(1) Tumorigenicity : Intratracheal injection of InAs and InP particles produced severe lung damage, but they showed no apparent tumorigenicity. Intraperitoneal injections of GaAs and GaP, and implantation of nickel alloy in thigh muscle of mice showed a significant tumorigenicity.
(2) Immunotoxicity : Number of polyclonal IgG production cells in spleens of mice treated with Be, Pt and Ni was increased, but that with Zr and Co showed no change. Be, Pt, and Ni seem to have the immunological cytotoxicity as antigenicity.
(3) Embryonic toxicity : Ni showed a strong effect on the embryonic growth at the stage of organogenesis.
(4) Mutagenicity : Be, Ga, Sb and As showed a DNA damaging activity in rec-assay, but no mutagenicity to Salmonella in Ames test. In SCE test using V79 cells, Sb, Be and As induced SCE.
(5) Metabolic study, general toxicity : Germanium and trimethylarsine are rapidly excreted in urine. In rats with renal lesion, the retention of these chemicals in the body was increased as compared with normal rats. General toxicity of As is in the order of arsine > triethylarsine > trimethylarsine. Sb affects the osmotic fragility of red blood cell membrane. Indium selectively affects renal tubules in low concentrations. These findings offer a basic toxicological data of these new metals.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 北川 泰久 他: "ノンコパ-トメント理論を用いたラットにおける微量元素の体内動態解析" 日本衛生学雑誌. 44. 1097-1106 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 和田 攻: "金属の量影響関係に関する研究" 日本産業衛生学会 報告書. 1-15 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka,A., et al.: "Comparative study on the tumorigenicity in mice of gallium arsenide,gallium phosphide and gallium oxide,following subcutaneous and intraperitoneal injections" Appl.Orgenemetal.Chem.4. 231-237 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木 忠男 他: "ディ-ゼル排気の長期吸入実験" 大気汚染学会. 25. 192-205 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] Teramoto,K.,et al.: "Effect of antimony on peripheral blood in mice" J.of Urban Living and Health Association. 34. 275-278 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, A., Wada, O.: "Purification and properties of biologically active chromium complex from bovine colostrum" J. Nutr.118. 39-45 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arakawa, Y., Wada, O.: "Suppression of cell proliferation by certain organotin." Tin and malignant cell growth. 84-103 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka, A., Hisanaga, A., Hirata, M., and Ishinishi, N.: "Comparative study on the tumorigenicity in mice of gallium arsenide, gallium phosphide and gallium oxide, following subcutaneous and intraperitoneal injections" Appl. Organometal. Chem.4(3). 231-237 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mohri, T., Hisanaga, A., Ishinishi, N.: "Arsenic intake and excretion by Japanese adults ; A 7-day duplicate diet study" Fd. Chem. Toxic.28(7). 521-529 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teramoto, K., Wakitani, F., Horiguchi, S., Tanaka, H. and Takashima, C: "Effect of antimony on peripheral blood in mice" J. of Urban Living and Health Association. 34. 275-278 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teramoto, K., Wakitani, F., Horiguchi, S., Tanaka, H., Hozu, S., and Takashima, C.: "Effect of antimony on peripheral blood in mice (II)" J. of Urban Living and Health Assoc.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosokawa. M., Endo, G., Kuroda, K. and Horiguchi, S: "Influence of sulfate, Ca and Mg on the acute toxicity of potassium dichromate to Daphnia similis" Bull. of Environ. Contamin and Toxicol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo, G., Kuroda, K., Okamoto, A. and Horiguchi, S.: "Dimethylarsinic acid(cacodylic acid) induces tetraploids in Chinese hamster cells" Bulletin of Environ. Contamin. and Toxicol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumoto, N.: "Transfer of acridine orange from mother mice to pre-implantation embroyos and its effect on embryonic growth" Jikeikai Med. J.35. 30-40 (1988)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Matsumoto, N.: "Application of vital staining with acrigin orange to investigation of embryonic growth at the stage of organogenesis" Jikeikai Med. J.36. 12-20 (1989)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamura, Y., Kaise, T., Takahashi, K., Mashiko, M. and Yamauchi, H.: "Metabolic fate of trimethylarsine oxide" Proceeding of the XIV International Congress on Occupational Health in the Chemical Industry (MEDI-CHEM). 6, 1-3 (1988)

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  • [Publications] Yamauchi, H., Takahashi, K., Mashiko, M. and Yamamura, Y.: "Biological monitoring of arsenic exposure of galliumarsenide and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabo-lites in urine and hair" Am. Ind. Hyg. Assoc. J.50. 606-612 (1989)

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  • [Publications] Yamauchi, H., Kaise, T., Takahashi, K. and Yamamura, Y.: "Toxicity and metabolism of trimethylarsine in mice and hamsters" Fundam. Appl. Toxicol.14. 399-407 (1990)

    • Description
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  • [Publications] Takahashi, K., Yamauchi, H. and Yamamura, Y.: "Toxicity and Metabolism of trimethylarsine" Proceedings of the 23rd International Congress on Occupational Health (ICOH). 403 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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