1990 Fiscal Year Final Research Report Summary
Analysis of Functional Cooperations between Organella in Responses to Medicines
| Project/Area Number |
63304054
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
ISHIBASHI Sadahiko. Inst. of Pharm. Sci., Hiroshima Univ. Sch. of Med, Professor, 医学部, 教授 (90012616)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Yasuyuki Fac. of Pharm. Sci., Hokkaido Univ., Professor, 薬学部, 教授 (00034041)
ICHIKAWA Atsushi Fac. of Pharm. Sci., Univ of Kyoto, Professor, 薬学部, 教授 (10025695)
NATORI Syunji Fac. of Pharm. Sci., Univ. of Tokyo, Professor, 薬学部, 教授 (50012662)
KATO Keitaro Fac. of Pharm. Sci., Kyushu Univ., Professor, 薬学部, 教授 (70037571)
ICHIHARA Akira Inst. for Enz. Sci., Univ. of Tokushima, Professor, 酸素科学研究センター, 教授 (40035374)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Cellular responses / Metabolic regulation / Organella / Cell membrane / Cell nucleus / Lysosomes / Endoplasmic reticulum / Cytoplasmic factors |
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| Research Abstract |
Cellular functions have usually been studied for each of individual reactions. But, since cell is composed of various organella including membranes and functioning on the basis of their cooperation, it is necessary to combine and generalize the information from various research groups. In this research, focus was taken on the functional cooperation in response to drug action, When the cooperation is very manifest.
1) Cooperations between cell membranes and nucleus : Mechanism functioning in the transduction of external information from cell membranes to nucleus was examined, especially for the stimulatory effect of growth factors, hormones, lectins, etc.
2) Cooperations between cytoplasmic factors and cell nuleus : Involvement of cytoplasmic hormone receptors, metabolic systems, etc. in nuclear functions was examined.
3) Cooperations between cell membranes, lysosomes, and endoplasmic reticulum : Functional alterations in these organella were followed at the time of endocytosis, and exocytosis and at the time of posttranslational processing.
4) Cooperations between cell membranes and cytoplasmic factors : Involvements of cytoplasmic factors in processing external information from cell membranes was analyzed especially in relation to the active complex formation by membranes and cytoplasmic components.
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