1989 Fiscal Year Final Research Report Summary
The role of vasoconstractile protein in renal artery and central catecholamine on renovascular hypertension
| Project/Area Number |
63480360
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Department of Urology, Chiba University, School of Medicine. |
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Principal Investigator |
NAKADA Teruhiro Chiba Univ.Dept.Urol.Assoc.Prof., 医学部, 助教授 (50009495)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof., 医学部, 教授 (10008229)
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof. (10008229)
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof. (10008229)
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof. (10008229)
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof. (10008229)
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| Project Period (FY) |
1988 – 1989
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| Keywords | hypothalamus / norepinephrine / non-collagen protein / collagen / renal artery stenosis / hypertension |
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| Research Abstract |
Two series of experiments were conducted whether the central catecholamine would participate in the elevation of blood pressure in 2-kidney, one clip (2K-1C)Goldblatt hypertensive rats. The effect of 6-OHDA injected intraventricularly before the induction of hypertension or after the establishment of hypertension was examined. The hypothalamic norepinephrine content of 2K-1C rats in acute phase is 50% lower (p 0.05) than that of sham rats, but norepicontent in pons is similar in these animals. The content of dopamine in hypothalamus,or pons is similar in 2K-1C rats and normotensive rats in acute phase.
The content of these monoamines either in hypothalamus or pons in 2K-1C rats in chronic phase is identical with that in sham rats. These findings suggest that hypothalamic norepinephrine participates in the development of hypertension in 2K-1C rats in the acute phase. Rats had been intraventricular injection of 6-OHDA before clipping the unilateral renal artery that caused selective ablation of the central noradrenergic neurons. Central catecholamines and the in vivo incorporation of 3H-proline into vascular non-collagen protein were determined in 2K-1C rats in the acute hypertensive stage and results were increased incorporation into the protein fraction. It is suggested that increased non-collagen protein synthesis in the mesenteric artery and the low level of hypothalamic norepinephrine concentration partidipates in the development of 2K-1C hypertension.
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[Publications] Nakada, T., Furuta, H., Katayama, T., Sumiya, H. and Shimazaki, J.: "The effect of adrenal surgery on plasma arterial natriuretic factor and sodium escape phenomenon in patients with primary aldosteronism." J.Urol., 142: 13-18, 1989.
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