1989 Fiscal Year Final Research Report Summary
Effect of dietary Calcium source to improvement of bone metabolism.
| Project/Area Number |
63480487
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
家政学
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| Research Institution | Japan Women's University |
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Principal Investigator |
EZAWA Ikuko Japan Women's University, Faculty of Home Economics, professor, 家政学部, 教授 (10060641)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Chikako Japan Women's University, Faculty of Home Economics, assistant, 家政学部, 助手 (60120771)
KAWANA Mitsuko Japan Women's University, Faculty of Home Economics, assistant professor, 家政学部, 助教授 (50060611)
NAKAHAMA Nobuko Japan Women's University, Faculty of Home Economics, professor, 家政学部, 教授 (90060590)
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| Project Period (FY) |
1988 – 1989
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| Keywords | osteoporosis model rat / ovariectomy / hard tissue preparation / breaking properties / calcium balance / BMD / MD / whey calcium |
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| Research Abstract |
Effects of Whey Ca on Bone Metabolism in Ovariectomized Osteoporosis Model Rats
In this study, we investigated the bioavailability of whey in diet as a Ca source, compared to CaCO_3 and CaHPO_4.5-weeks-female rats were ovariecotomized, and then they were fed on the low Ca diet(Ca:0.01%) for 27days. After that, these rats were divided into three groups, whey, CaCO_3 and CaHPO_4. They were estimated Ca balance, microdensitometry and breaking properties of bone. As a result, there were no significant differences in serum Ca levels, food efficiency ratio and body weight gain between those three groups. On the other hand, in whey Ca diet group, the urinary Ca excretion is higher than that of CaCO_3 and CaHPO_4 diet groups. And in whey and CaHPO_4 diet groups, the femur breaking properties and the parameters of micro densitometry, SIGMA GS, SIGMA GS/D, GSmin, GSmax, increased compared to CaCO_3 diet group. And those parameters of whey diet group were a little higher than that of CaHPO_4 diet group (not significant). These results clearly suggest that the whey, as a Ca source, has a beneficial effect on increasing bone strength.
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